1j9i

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[[Image:1j9i.gif|left|200px]]
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[[Image:1j9i.png|left|200px]]
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{{STRUCTURE_1j9i| PDB=1j9i | SCENE= }}
{{STRUCTURE_1j9i| PDB=1j9i | SCENE= }}
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'''STRUCTURE OF THE DNA BINDING DOMAIN OF THE GPNU1 SUBUNIT OF LAMBDA TERMINASE'''
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===STRUCTURE OF THE DNA BINDING DOMAIN OF THE GPNU1 SUBUNIT OF LAMBDA TERMINASE===
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==Overview==
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Terminase enzymes mediate genome "packaging" during the reproduction of DNA viruses. In lambda, the gpNu1 subunit guides site-specific assembly of terminase onto DNA. The structure of the dimeric DNA binding domain of gpNu1 was solved using nuclear magnetic resonance spectroscopy. Its fold contains a unique winged helix-turn-helix (wHTH) motif within a novel scaffold. Surprisingly, a predicted P loop ATP binding motif is in fact the wing of the DNA binding motif. Structural and genetic analysis has identified determinants of DNA recognition specificity within the wHTH motif and the DNA recognition sequence. The structure reveals an unexpected DNA binding mode and provides a mechanistic basis for the concerted action of gpNu1 and Escherichia coli integration host factor during assembly of the packaging machinery.
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(as it appears on PubMed at http://www.pubmed.gov), where 12049735 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12049735}}
==About this Structure==
==About this Structure==
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1J9I is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_lambda Enterobacteria phage lambda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J9I OCA].
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1J9I is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_lambda Enterobacteria phage lambda]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J9I OCA].
==Reference==
==Reference==
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[[Category: Viral assembly]]
[[Category: Viral assembly]]
[[Category: Winged helix-turn-helix]]
[[Category: Winged helix-turn-helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:57:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 14:43:05 2008''

Revision as of 11:43, 1 July 2008

Image:1j9i.png

Template:STRUCTURE 1j9i

STRUCTURE OF THE DNA BINDING DOMAIN OF THE GPNU1 SUBUNIT OF LAMBDA TERMINASE

Template:ABSTRACT PUBMED 12049735

About this Structure

1J9I is a Single protein structure of sequence from Enterobacteria phage lambda. Full experimental information is available from OCA.

Reference

Insights into specific DNA recognition during the assembly of a viral genome packaging machine., de Beer T, Fang J, Ortega M, Yang Q, Maes L, Duffy C, Berton N, Sippy J, Overduin M, Feiss M, Catalano CE, Mol Cell. 2002 May;9(5):981-91. PMID:12049735

Page seeded by OCA on Tue Jul 1 14:43:05 2008

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