1gx7

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Revision as of 14:12, 20 November 2007

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BEST MODEL OF THE ELECTRON TRANSFER COMPLEX BETWEEN CYTOCHROME C3 AND [FE]-HYDROGENASE

Overview

Cytochrome c(3) (M(r) 13000) is a low redox potential cytochrome specific, of the anaerobic metabolism in sulfate-reducing bacteria. This tetrahemic, cytochrome is an intermediate between the [Fe]-hydrogenase and the, cytochrome Hmc in Desulfovibrio vulgaris Hildenborough strain. The present, work describes the structural model of the cytochrome, c(3)-[Fe]-hydrogenase complex obtained by nuclear magnetic resonance, restrained docking. This model connects the distal cluster of the, [Fe]-hydrogenase to heme 4 of the cytochrome, the same heme found in the, interaction with cytochrome Hmc. This result gives evidence that, cytochrome c(3) is an electron shuttle between the periplasmic hydrogenase, and the Hmc membrane-bound complex.

About this Structure

1GX7 is a Protein complex structure of sequences from Desulfovibrio vulgaris with FE2, CYN, SF4, PDT, CMO and HEC as ligands. Active as Ferredoxin hydrogenase, with EC number 1.12.7.2 Full crystallographic information is available from OCA.

Reference

The cytochrome c3-[Fe]-hydrogenase electron-transfer complex: structural model by NMR restrained docking., ElAntak L, Morelli X, Bornet O, Hatchikian C, Czjzek M, Dolla A, Guerlesquin F, FEBS Lett. 2003 Jul 31;548(1-3):1-4. PMID:12885397

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