1jaj

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{{STRUCTURE_1jaj| PDB=1jaj | SCENE= }}
{{STRUCTURE_1jaj| PDB=1jaj | SCENE= }}
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'''Solution Structure of DNA Polymerase X from the African Swine Fever Virus'''
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===Solution Structure of DNA Polymerase X from the African Swine Fever Virus===
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==Overview==
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DNA polymerase X (Pol X) from the African swine fever virus (ASFV) specifically binds intermediates in the single-nucleotide base-excision repair process, an activity indicative of repair function. In addition, Pol X catalyzes DNA polymerization with low nucleotide-insertion fidelity. The structural mechanisms by which DNA polymerases confer high or low fidelity in DNA polymerization remain to be elucidated. The three-dimensional structure of Pol X has been determined. Unlike other DNA polymerases, Pol X is formed from only a palm and a C-terminal subdomain. Pol X has a novel palm subdomain fold, containing a positively charged helix at the DNA binding surface. Purine deoxynucleoside triphosphate (dNTP) substrates bind between the palm and C-terminal subdomain, at a dNTP-binding helix, and induce a unique conformation in Pol X. The purine dNTP-bound conformation and high binding affinity for dGTP-Mg(2+) of Pol X may contribute to its low fidelity.
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(as it appears on PubMed at http://www.pubmed.gov), where 11685238 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11685238}}
==About this Structure==
==About this Structure==
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1JAJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/African_swine_fever_virus African swine fever virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JAJ OCA].
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1JAJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/African_swine_fever_virus African swine fever virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JAJ OCA].
==Reference==
==Reference==
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[[Category: Shin, R.]]
[[Category: Shin, R.]]
[[Category: Cis peptide]]
[[Category: Cis peptide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:58:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 16:46:11 2008''

Revision as of 13:53, 1 July 2008

Image:1jaj.png

Template:STRUCTURE 1jaj

Solution Structure of DNA Polymerase X from the African Swine Fever Virus

Template:ABSTRACT PUBMED 11685238

About this Structure

1JAJ is a Single protein structure of sequence from African swine fever virus. Full experimental information is available from OCA.

Reference

Solution structure of a viral DNA repair polymerase., Maciejewski MW, Shin R, Pan B, Marintchev A, Denninger A, Mullen MA, Chen K, Gryk MR, Mullen GP, Nat Struct Biol. 2001 Nov;8(11):936-41. PMID:11685238

Page seeded by OCA on Tue Jul 1 16:46:11 2008

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