1jat

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[[Image:1jat.gif|left|200px]]
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{{STRUCTURE_1jat| PDB=1jat | SCENE= }}
{{STRUCTURE_1jat| PDB=1jat | SCENE= }}
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'''Mms2/Ubc13 Ubiquitin Conjugating Enzyme Complex'''
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===Mms2/Ubc13 Ubiquitin Conjugating Enzyme Complex===
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==Overview==
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While the signaling properties of ubiquitin depend on the topology of polyubiquitin chains, little is known concerning the molecular basis of specificity in chain assembly and recognition. UEV/Ubc complexes have been implicated in the assembly of Lys63-linked polyubiquitin chains that act as a novel signal in postreplicative DNA repair and I kappa B alpha kinase activation. The crystal structure of the Mms2/Ubc13 heterodimer shows the active site of Ubc13 at the intersection of two channels that are potential binding sites for the two substrate ubiquitins. Mutations that destabilize the heterodimer interface confer a marked UV sensitivity, providing direct evidence that the intact heterodimer is necessary for DNA repair. Selective mutations in the channels suggest a molecular model for specificity in the assembly of Lys63-linked polyubiquitin signals.
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The line below this paragraph, {{ABSTRACT_PUBMED_11440714}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11440714 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11440714}}
==About this Structure==
==About this Structure==
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[[Category: Ubiquitin-conjugating enzyme]]
[[Category: Ubiquitin-conjugating enzyme]]
[[Category: Uev]]
[[Category: Uev]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:59:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 18:54:48 2008''

Revision as of 15:57, 1 July 2008

Image:1jat.png

Template:STRUCTURE 1jat

Mms2/Ubc13 Ubiquitin Conjugating Enzyme Complex

Template:ABSTRACT PUBMED 11440714

About this Structure

1JAT is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Molecular insights into polyubiquitin chain assembly: crystal structure of the Mms2/Ubc13 heterodimer., VanDemark AP, Hofmann RM, Tsui C, Pickart CM, Wolberger C, Cell. 2001 Jun 15;105(6):711-20. PMID:11440714

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