1jb3

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1jb3.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1jb3.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1jb3| PDB=1jb3 | SCENE= }}
{{STRUCTURE_1jb3| PDB=1jb3 | SCENE= }}
-
'''The Laminin-Binding Domain of Agrin is structurally related to N-TIMP-1'''
+
===The Laminin-Binding Domain of Agrin is structurally related to N-TIMP-1===
-
==Overview==
+
<!--
-
Agrin is the key organizer of postsynaptic differentiation at the neuromuscular junction. This organization activity requires the binding of agrin to the synaptic basal lamina. Binding is conferred by the N-terminal agrin (NtA) domain, which mediates a high-affinity interaction with the coiled coil domain of laminins. Here, we report the crystal structure of chicken NtA at 1.6 A resolution. The structure reveals that NtA harbors an oligosaccharide/oligonucleotide-binding fold with several possible sites for the interaction with different ligands. A high structural similarity of NtA with the protease inhibition domain in tissue inhibitor of metalloproteinases-1 (TIMP-1) supports the idea of additional functions of agrin besides synaptogenic activity.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11473262}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11473262 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11473262}}
==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Ob-fold]]
[[Category: Ob-fold]]
[[Category: Timp]]
[[Category: Timp]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:00:11 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 19:56:59 2008''

Revision as of 16:57, 1 July 2008

Image:1jb3.png

Template:STRUCTURE 1jb3

The Laminin-Binding Domain of Agrin is structurally related to N-TIMP-1

Template:ABSTRACT PUBMED 11473262

About this Structure

1JB3 is a Single protein structure of sequence from Gallus gallus. Full crystallographic information is available from OCA.

Reference

The laminin-binding domain of agrin is structurally related to N-TIMP-1., Stetefeld J, Jenny M, Schulthess T, Landwehr R, Schumacher B, Frank S, Ruegg MA, Engel J, Kammerer RA, Nat Struct Biol. 2001 Aug;8(8):705-9. PMID:11473262

Page seeded by OCA on Tue Jul 1 19:56:59 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1jb3"
Personal tools