This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1jb7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1jb7.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1jb7.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1jb7| PDB=1jb7 | SCENE= }}
{{STRUCTURE_1jb7| PDB=1jb7 | SCENE= }}
-
'''DNA G-Quartets in a 1.86 A Resolution Structure of an Oxytricha nova Telomeric Protein-DNA Complex'''
+
===DNA G-Quartets in a 1.86 A Resolution Structure of an Oxytricha nova Telomeric Protein-DNA Complex===
-
==Overview==
+
<!--
-
The Oxytricha nova telomere end binding protein (OnTEBP) recognizes, binds and protects the single-stranded 3'-terminal DNA extension found at the ends of macronuclear chromosomes. The structure of this complex shows that the single strand GGGGTTTTGGGG DNA binds in a deep cleft between the two protein subunits of OnTEBP, adopting a non-helical and irregular conformation. In extending the resolution limit of this structure to 1.86 A, we were surprised to find a G-quartet linked dimer of the GGGGTTTTGGGG DNA also packing within the crystal lattice and interacting with the telomere end binding protein. The G-quartet DNA exhibits the same structure and topology as previously observed in solution by NMR with diagonally crossing d(TTTT) loops at either end of the four-stranded helix. Additionally, the crystal structure reveals clearly visible Na(+), and specific patterns of bound water molecules in the four non-equivalent grooves. Although the G-quartet:protein contact surfaces are modest and might simply represent crystal packing interactions, it is interesting to speculate that the two types of telomeric DNA-protein interactions observed here might both be important in telomere biology.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11428895}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11428895 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11428895}}
==About this Structure==
==About this Structure==
Line 29: Line 33:
[[Category: Sodium ion]]
[[Category: Sodium ion]]
[[Category: Telomere-binding protein]]
[[Category: Telomere-binding protein]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:00:28 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 19:57:21 2008''

Revision as of 16:57, 1 July 2008

Image:1jb7.png

Template:STRUCTURE 1jb7

DNA G-Quartets in a 1.86 A Resolution Structure of an Oxytricha nova Telomeric Protein-DNA Complex

Template:ABSTRACT PUBMED 11428895

About this Structure

1JB7 is a Protein complex structure of sequences from Sterkiella nova. Full crystallographic information is available from OCA.

Reference

DNA G-quartets in a 1.86 A resolution structure of an Oxytricha nova telomeric protein-DNA complex., Horvath MP, Schultz SC, J Mol Biol. 2001 Jul 6;310(2):367-77. PMID:11428895

Page seeded by OCA on Tue Jul 1 19:57:21 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1jb7"
Personal tools