1jbr

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[[Image:1jbr.gif|left|200px]]
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{{STRUCTURE_1jbr| PDB=1jbr | SCENE= }}
{{STRUCTURE_1jbr| PDB=1jbr | SCENE= }}
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'''Crystal Structure of the Ribotoxin Restrictocin and a 31-mer SRD RNA Inhibitor'''
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===Crystal Structure of the Ribotoxin Restrictocin and a 31-mer SRD RNA Inhibitor===
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==Overview==
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The cytotoxin sarcin disrupts elongation factor binding and protein synthesis by specifically cleaving one phosphodiester bond in ribosomes. To elucidate the molecular basis of toxin action, we determined three cocrystal structures of the sarcin homolog restrictocin bound to different analogs that mimic the target sarcin/ricin loop (SRL) structure of the rat 28S rRNA. In these structures, restrictocin contacts the bulged-G motif and an unfolded form of the tetraloop of the SRL RNA. In one structure, toxin loops guide selection of the target site by contacting the base critical for recognition (G4319) and the surrounding S-shaped backbone. In another structure, base flipping of the tetraloop enables cleavage by placing the target nucleotide in the active site with the nucleophile nearly inline for attack on the scissile bond. These structures provide the first views of how a site-specific protein endonuclease recognizes and cleaves a folded RNA substrate.
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The line below this paragraph, {{ABSTRACT_PUBMED_11685244}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11685244 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11685244}}
==About this Structure==
==About this Structure==
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[[Category: Sarcin/ricin domain]]
[[Category: Sarcin/ricin domain]]
[[Category: Specific recognition]]
[[Category: Specific recognition]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:01:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 19:59:13 2008''

Revision as of 16:59, 1 July 2008

Image:1jbr.png

Template:STRUCTURE 1jbr

Crystal Structure of the Ribotoxin Restrictocin and a 31-mer SRD RNA Inhibitor

Template:ABSTRACT PUBMED 11685244

About this Structure

1JBR is a Single protein structure of sequence from Aspergillus restrictus. Full crystallographic information is available from OCA.

Reference

Crystal structures of restrictocin-inhibitor complexes with implications for RNA recognition and base flipping., Yang X, Gerczei T, Glover LT, Correll CC, Nat Struct Biol. 2001 Nov;8(11):968-73. PMID:11685244

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