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1jcd

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{{STRUCTURE_1jcd| PDB=1jcd | SCENE= }}
{{STRUCTURE_1jcd| PDB=1jcd | SCENE= }}
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'''Crystal Structure of a Novel Alanine-Zipper Trimer at 1.3 A Resolution, I6A,L9A,V13A,L16A,V20A,L23A,V27A,M30A,V34A,L48A,M51A mutations'''
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===Crystal Structure of a Novel Alanine-Zipper Trimer at 1.3 A Resolution, I6A,L9A,V13A,L16A,V20A,L23A,V27A,M30A,V34A,L48A,M51A mutations===
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==Overview==
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A major challenge in protein folding is to identify and quantify specific structural determinants that allow native proteins to acquire their unique folded structures. Here we report the engineering of a 52-residue protein (Ala-14) that contains exclusively alanine residues at the hydrophobic a and d positions of a natural heptad-repeat sequence. Ala-14 is unfolded under normal solution conditions yet forms a parallel three-stranded alpha-helical coiled coil in crystals. Ala-14 trimers in the solid state associate with each other through the pairing of polar side chains and formation of an extended network of water-mediated hydrogen bonds. In contrast to the classical view that local intramolecular tertiary interactions dictate the three-dimensional structure of small single-domain proteins, Ala-14 shows that long range intermolecular interactions can be essential in determining the metastable alanine-zipper structure. A similar interplay between short range local and longer range global forces may underlie the conformational properties of the growing class of natively unstructured proteins in biological processes.
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{{ABSTRACT_PUBMED_12368282}}
==About this Structure==
==About this Structure==
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[[Category: Lipoprotein]]
[[Category: Lipoprotein]]
[[Category: Protein folding]]
[[Category: Protein folding]]
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Revision as of 17:01, 1 July 2008

Image:1jcd.png

Template:STRUCTURE 1jcd

Crystal Structure of a Novel Alanine-Zipper Trimer at 1.3 A Resolution, I6A,L9A,V13A,L16A,V20A,L23A,V27A,M30A,V34A,L48A,M51A mutations

Template:ABSTRACT PUBMED 12368282

About this Structure

1JCD is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

An alanine-zipper structure determined by long range intermolecular interactions., Liu J, Lu M, J Biol Chem. 2002 Dec 13;277(50):48708-13. Epub 2002 Oct 3. PMID:12368282

Page seeded by OCA on Tue Jul 1 20:01:10 2008

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