1gyw

From Proteopedia

(Difference between revisions)
Jump to: navigation, search

OCA (Talk | contribs)
(New page: 200px<br /><applet load="1gyw" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gyw, resolution 2.40&Aring;" /> '''GAMMA-ADAPTIN APPEND...)
Next diff →

Revision as of 14:14, 20 November 2007

Image:1gyw.jpg

1gyw, resolution 2.40Å

Drag the structure with the mouse to rotate

GAMMA-ADAPTIN APPENDAGE DOMAIN FROM CLATHRIN ADAPTOR AP1 A753D MUTANT

Overview

The AP1 complex is one of a family of heterotetrameric clathrin-adaptor, complexes involved in vesicular trafficking between the Golgi and, endosomes. The complex has two large subunits, gamma and beta1, which can, be divided into trunk, hinge, and appendage domains. The 1.8 A resolution, structure of the gamma appendage is presented. The binding site for the, known gamma appendage ligand gamma-synergin is mapped through creation of, point mutations designed on the basis of the structure. We also show that, Eps15, a protein believed to be involved in vesicle formation at the, plasma membrane, is also a ligand of gamma appendage and binds to the same, site as gamma-synergin. This observation explains the demonstrated, brefeldinA (BFA)-sensitive colocalization of Eps15 and AP1 at the Golgi, complex.

About this Structure

1GYW is a Single protein structure of sequence from Mus musculus with CL as ligand. Full crystallographic information is available from OCA.

Reference

Gamma-adaptin appendage domain: structure and binding site for Eps15 and gamma-synergin., Kent HM, McMahon HT, Evans PR, Benmerah A, Owen DJ, Structure. 2002 Aug;10(8):1139-48. PMID:12176391

Page seeded by OCA on Tue Nov 20 16:21:33 2007

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1gyw"
Personal tools