1jd4

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[[Image:1jd4.gif|left|200px]]
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{{STRUCTURE_1jd4| PDB=1jd4 | SCENE= }}
{{STRUCTURE_1jd4| PDB=1jd4 | SCENE= }}
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'''Crystal Structure of DIAP1-BIR2'''
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===Crystal Structure of DIAP1-BIR2===
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==Overview==
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The inhibitor of apoptosis protein DIAP1 suppresses apoptosis in Drosophila, with the second BIR domain (BIR2) playing an important role. Three proteins, Hid, Grim, and Reaper, promote apoptosis, in part by binding to DIAP1 through their conserved N-terminal sequences. The crystal structures of DIAP1-BIR2 by itself and in complex with the N-terminal peptides from Hid and Grim reveal that these peptides bind a surface groove on DIAP1, with the first four amino acids mimicking the binding of the Smac tetrapeptide to XIAP. The next 3 residues also contribute to binding through hydrophobic interactions. Interestingly, peptide binding induces the formation of an additional alpha helix in DIAP1. Our study reveals the structural conservation and diversity necessary for the binding of IAPs by the Drosophila Hid/Grim/Reaper and the mammalian Smac proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 11511363 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11511363}}
==About this Structure==
==About this Structure==
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[[Category: Iap]]
[[Category: Iap]]
[[Category: Zinc-binding]]
[[Category: Zinc-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:04:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:03:25 2008''

Revision as of 17:03, 1 July 2008

Image:1jd4.png

Template:STRUCTURE 1jd4

Crystal Structure of DIAP1-BIR2

Template:ABSTRACT PUBMED 11511363

About this Structure

1JD4 is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Structural analysis of a functional DIAP1 fragment bound to grim and hid peptides., Wu JW, Cocina AE, Chai J, Hay BA, Shi Y, Mol Cell. 2001 Jul;8(1):95-104. PMID:11511363

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