1jes

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{{STRUCTURE_1jes| PDB=1jes | SCENE= }}
{{STRUCTURE_1jes| PDB=1jes | SCENE= }}
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'''Crystal Structure of a Copper-Mediated Base Pair in DNA'''
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===Crystal Structure of a Copper-Mediated Base Pair in DNA===
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==Overview==
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Stable and selective DNA base pairing by metal coordination was recently demonstrated with nucleotides containing complementary pyridine-2,6-dicarboxylate (Dipic) and pyridine (Py) bases (Meggers, E.; Holland, P. L.; Tolman; W. B.; Romesberg, F. E.; Schultz, P. G. J. Am. Chem. Soc. 2000, 122, 10714-10715). To understand the structural consequences of introducing this novel base pair into DNA we have solved the crystal structure of a duplex containing the metallo-base pair. The structure shows that the bases pair as designed, but in a Z-DNA conformation. The structure also provides a structural explanation for the B- to Z-DNA transition in this duplex. Further solution studies demonstrate that the metallo-base pair is compatible with Z- or B-DNA conformations, depending on the duplex sequence.
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(as it appears on PubMed at http://www.pubmed.gov), where 11734038 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11734038}}
==About this Structure==
==About this Structure==
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[[Category: Unnatural]]
[[Category: Unnatural]]
[[Category: Z-dna]]
[[Category: Z-dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:08:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:08:02 2008''

Revision as of 17:08, 1 July 2008

Image:1jes.png

Template:STRUCTURE 1jes

Crystal Structure of a Copper-Mediated Base Pair in DNA

Template:ABSTRACT PUBMED 11734038

About this Structure

Full crystallographic information is available from OCA.

Reference

Structure of a copper-mediated base pair in DNA., Atwell S, Meggers E, Spraggon G, Schultz PG, J Am Chem Soc. 2001 Dec 12;123(49):12364-7. PMID:11734038

Page seeded by OCA on Tue Jul 1 20:08:02 2008

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