1jf1

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[[Image:1jf1.gif|left|200px]]
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{{STRUCTURE_1jf1| PDB=1jf1 | SCENE= }}
{{STRUCTURE_1jf1| PDB=1jf1 | SCENE= }}
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'''Crystal structure of HLA-A2*0201 in complex with a decameric altered peptide ligand from the MART-1/Melan-A'''
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===Crystal structure of HLA-A2*0201 in complex with a decameric altered peptide ligand from the MART-1/Melan-A===
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==Overview==
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We have determined high-resolution crystal structures of the complexes of HLA-A2 molecules with two modified immunodominant peptides from the melanoma tumor-associated protein Melan-A/Melanoma Ag recognized by T cells-1. The two peptides, a decamer and nonamer with overlapping sequences (ELAGIGILTV and ALGIGILTV), are modified in the second residue to increase their affinity for HLA-A2. The modified decamer is more immunogenic than the natural peptide and a candidate for peptide-based melanoma immunotherapy. The crystal structures at 1.8 and 2.15 A resolution define the differences in binding modes of the modified peptides, including different clusters of water molecules that appear to stabilize the peptide-HLA interaction. The structures suggest both how the wild-type peptides would bind and how three categories of cytotoxic T lymphocytes with differing fine specificity might recognize the two peptides.
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(as it appears on PubMed at http://www.pubmed.gov), where 11544315 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11544315}}
==About this Structure==
==About this Structure==
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[[Category: Tumor immunity]]
[[Category: Tumor immunity]]
[[Category: Vaccination]]
[[Category: Vaccination]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:08:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:08:45 2008''

Revision as of 17:08, 1 July 2008

Image:1jf1.png

Template:STRUCTURE 1jf1

Crystal structure of HLA-A2*0201 in complex with a decameric altered peptide ligand from the MART-1/Melan-A

Template:ABSTRACT PUBMED 11544315

About this Structure

1JF1 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structures of two closely related but antigenically distinct HLA-A2/melanocyte-melanoma tumor-antigen peptide complexes., Sliz P, Michielin O, Cerottini JC, Luescher I, Romero P, Karplus M, Wiley DC, J Immunol. 2001 Sep 15;167(6):3276-84. PMID:11544315

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