1jfg

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{{STRUCTURE_1jfg| PDB=1jfg | SCENE= }}
{{STRUCTURE_1jfg| PDB=1jfg | SCENE= }}
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'''TRICHODIENE SYNTHASE FROM FUSARIUM SPOROTRICHIOIDES COMPLEXED WITH DIPHOSPHATE'''
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===TRICHODIENE SYNTHASE FROM FUSARIUM SPOROTRICHIOIDES COMPLEXED WITH DIPHOSPHATE===
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==Overview==
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The x-ray crystal structure of recombinant trichodiene synthase from Fusarium sporotrichioides has been determined to 2.5-A resolution, both unliganded and complexed with inorganic pyrophosphate. This reaction product coordinates to three Mg(2+) ions near the mouth of the active site cleft. A comparison of the liganded and unliganded structures reveals a ligand-induced conformational change that closes the mouth of the active site cleft. Binding of the substrate farnesyl diphosphate similarly may trigger this conformational change, which would facilitate catalysis by protecting reactive carbocationic intermediates in the cyclization cascade. Trichodiene synthase also shares significant structural similarity with other sesquiterpene synthases despite a lack of significant sequence identity. This similarity indicates divergence from a common ancestor early in the evolution of terpene biosynthesis.
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(as it appears on PubMed at http://www.pubmed.gov), where 11698643 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11698643}}
==About this Structure==
==About this Structure==
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[[Category: Rynkiewicz, M J.]]
[[Category: Rynkiewicz, M J.]]
[[Category: Terpenoid synthase fold]]
[[Category: Terpenoid synthase fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:09:54 2008''

Revision as of 17:09, 1 July 2008

Image:1jfg.png

Template:STRUCTURE 1jfg

TRICHODIENE SYNTHASE FROM FUSARIUM SPOROTRICHIOIDES COMPLEXED WITH DIPHOSPHATE

Template:ABSTRACT PUBMED 11698643

About this Structure

1JFG is a Single protein structure of sequence from Fusarium sporotrichioides. Full crystallographic information is available from OCA.

Reference

Structure of trichodiene synthase from Fusarium sporotrichioides provides mechanistic inferences on the terpene cyclization cascade., Rynkiewicz MJ, Cane DE, Christianson DW, Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13543-8. Epub 2001 Nov 6. PMID:11698643

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