1jfn

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[[Image:1jfn.jpg|left|200px]]
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{{Seed}}
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[[Image:1jfn.png|left|200px]]
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{{STRUCTURE_1jfn| PDB=1jfn | SCENE= }}
{{STRUCTURE_1jfn| PDB=1jfn | SCENE= }}
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'''SOLUTION STRUCTURE OF HUMAN APOLIPOPROTEIN(A) KRINGLE IV TYPE 6'''
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===SOLUTION STRUCTURE OF HUMAN APOLIPOPROTEIN(A) KRINGLE IV TYPE 6===
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==Overview==
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The structure of apo(a) KIVT6 was investigated by two- and three-dimensional homo- and heteronuclear NMR spectroscopy. The solution structure of apo(a) KIVT6 contains only a small amount of regular secondary structure elements, comprising a short piece of antiparallel beta-sheet formed by residues Trp62-Tyr64 and Trp72-Tyr74, a short piece of parallel beta-sheet formed by the residues Cys1-Tyr2 and Thr78-Gln79, and a small 3(10)-helix within residues Thr38-Tyr40. The backbone as well as the side chains are arranged in a way similar to those of apo(a) KIVT7, apo(a) KIVT10, and plasminogen K4. We determined additionally the K(d) value of 0.31 +/- 0.04 mM for the binding of epsilon-aminocaproic acid (EACA) to apo(a) KIVT6 and mapped the binding region on apo(a) KIVT6 by means of chemical shift perturbation. This lysine binding activity, which was reported to occur within apo(a) KIVT5-8, is functionally different from the lysine binding activity found for apo(a) KIVT10.
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The line below this paragraph, {{ABSTRACT_PUBMED_11781107}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11781107 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11781107}}
==About this Structure==
==About this Structure==
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1JFN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JFN OCA].
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1JFN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JFN OCA].
==Reference==
==Reference==
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[[Category: Kringle domain]]
[[Category: Kringle domain]]
[[Category: Protein-protein recognition]]
[[Category: Protein-protein recognition]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:10:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:10:35 2008''

Revision as of 17:10, 1 July 2008

Image:1jfn.png

Template:STRUCTURE 1jfn

SOLUTION STRUCTURE OF HUMAN APOLIPOPROTEIN(A) KRINGLE IV TYPE 6

Template:ABSTRACT PUBMED 11781107

About this Structure

1JFN is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of human apolipoprotein(a) kringle IV type 6., Maderegger B, Bermel W, Hrzenjak A, Kostner GM, Sterk H, Biochemistry. 2002 Jan 15;41(2):660-8. PMID:11781107

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