1jfp

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{{STRUCTURE_1jfp| PDB=1jfp | SCENE= }}
{{STRUCTURE_1jfp| PDB=1jfp | SCENE= }}
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'''Structure of bovine rhodopsin (dark adapted)'''
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===Structure of bovine rhodopsin (dark adapted)===
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==Overview==
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Activation of G-protein coupled receptors (GPCR) is not yet understood. A recent structure showed most of rhodopsin in the ground (not activated) state of the GPCR, but the cytoplasmic face, which couples to the G protein in signal transduction, was not well-defined. We have determined an experimental three-dimensional structure for rhodopsin in the unactivated state, which shows good agreement with the crystal structure in the transmembrane domain. This new structure defines the cytoplasmic face of rhodopsin. The G-protein binding site can be mapped. The same experimental approach yields a preliminary structure of the cytoplasmic face in the activated (metarhodopsin II) receptor. Differences between the two structures suggest how the receptor is activated to couple with transducin.
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The line below this paragraph, {{ABSTRACT_PUBMED_11570894}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11570894 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11570894}}
==About this Structure==
==About this Structure==
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1JFP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JFP OCA].
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1JFP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JFP OCA].
==Reference==
==Reference==
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[[Category: Yeagle, P L.]]
[[Category: Yeagle, P L.]]
[[Category: G-protein coupled receptor]]
[[Category: G-protein coupled receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:10:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:10:42 2008''

Revision as of 17:10, 1 July 2008

Image:1jfp.png

Template:STRUCTURE 1jfp

Structure of bovine rhodopsin (dark adapted)

Template:ABSTRACT PUBMED 11570894

About this Structure

1JFP is a Single protein structure of sequence from Bos taurus. Full experimental information is available from OCA.

Reference

Studies on the structure of the G-protein-coupled receptor rhodopsin including the putative G-protein binding site in unactivated and activated forms., Yeagle PL, Choi G, Albert AD, Biochemistry. 2001 Oct 2;40(39):11932-7. PMID:11570894

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