We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

1jfv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1jfv.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1jfv.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1jfv| PDB=1jfv | SCENE= }}
{{STRUCTURE_1jfv| PDB=1jfv | SCENE= }}
-
'''X-Ray Structure of oxidised C10S, C15A arsenate reductase from pI258'''
+
===X-Ray Structure of oxidised C10S, C15A arsenate reductase from pI258===
-
==Overview==
+
<!--
-
Arsenate reductase (ArsC) from Staphylococcus aureus plasmid pI258 plays a role in bacterial heavy metal resistance and catalyzes the reduction of arsenate to arsenite. The structures of the oxidized and reduced forms of ArsC were solved. ArsC has the PTPase I fold typical for low molecular weight tyrosine phosphatases (LMW PTPases). Remarkably, kinetic experiments show that pI258 ArsC also catalyzes the tyrosine phosphatase reaction in addition to arsenate reduction. These results provide evidence that ArsC from pI258 evolved from LMW PTPase by the grafting of a redox function onto a pre-existing catalytic site and that its evolutionary origin is different from those of arsenate reductases from Escherichia coli plasmid R773 and from Saccharomyces cerevisiae. The mechanism proposed here for the catalysis of arsenate reduction by pI258 ArsC involves a nucleophilic attack by Cys 10 on arsenate, the formation of a covalent intermediate and the transport of oxidative equivalents by a disulfide cascade. The reaction is associated with major structural changes in the ArsC.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11573087}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11573087 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11573087}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: Perchlorate]]
[[Category: Perchlorate]]
[[Category: Potassium]]
[[Category: Potassium]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:10:30 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:11:10 2008''

Revision as of 17:11, 1 July 2008

Image:1jfv.png

Template:STRUCTURE 1jfv

X-Ray Structure of oxidised C10S, C15A arsenate reductase from pI258

Template:ABSTRACT PUBMED 11573087

About this Structure

1JFV is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

Arsenate reductase from S. aureus plasmid pI258 is a phosphatase drafted for redox duty., Zegers I, Martins JC, Willem R, Wyns L, Messens J, Nat Struct Biol. 2001 Oct;8(10):843-7. PMID:11573087

Page seeded by OCA on Tue Jul 1 20:11:10 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1jfv"
Personal tools