1jg5

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{{STRUCTURE_1jg5| PDB=1jg5 | SCENE= }}
{{STRUCTURE_1jg5| PDB=1jg5 | SCENE= }}
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'''CRYSTAL STRUCTURE OF RAT GTP CYCLOHYDROLASE I FEEDBACK REGULATORY PROTEIN, GFRP'''
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===CRYSTAL STRUCTURE OF RAT GTP CYCLOHYDROLASE I FEEDBACK REGULATORY PROTEIN, GFRP===
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==Overview==
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Tetrahydrobiopterin, the cofactor required for hydroxylation of aromatic amino acids regulates its own synthesis in mammals through feedback inhibition of GTP cyclohydrolase I. This mechanism is mediated by a regulatory subunit called GTP cyclohydrolase I feedback regulatory protein (GFRP). The 2.6 A resolution crystal structure of rat GFRP shows that the protein forms a pentamer. This indicates a model for the interaction of mammalian GTP cyclohydrolase I with its regulator, GFRP. Kinetic investigations of human GTP cyclohydrolase I in complex with rat and human GFRP showed similar regulatory effects of both GFRP proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 11580249 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11580249}}
==About this Structure==
==About this Structure==
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[[Category: Alpha/beta structure]]
[[Category: Alpha/beta structure]]
[[Category: Beta sheet]]
[[Category: Beta sheet]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:11:57 2008''

Revision as of 17:11, 1 July 2008

Image:1jg5.png

Template:STRUCTURE 1jg5

CRYSTAL STRUCTURE OF RAT GTP CYCLOHYDROLASE I FEEDBACK REGULATORY PROTEIN, GFRP

Template:ABSTRACT PUBMED 11580249

About this Structure

1JG5 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Crystal structure of rat GTP cyclohydrolase I feedback regulatory protein, GFRP., Bader G, Schiffmann S, Herrmann A, Fischer M, Gutlich M, Auerbach G, Ploom T, Bacher A, Huber R, Lemm T, J Mol Biol. 2001 Oct 5;312(5):1051-7. PMID:11580249

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