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1jh3

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[[Image:1jh3.gif|left|200px]]
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{{STRUCTURE_1jh3| PDB=1jh3 | SCENE= }}
{{STRUCTURE_1jh3| PDB=1jh3 | SCENE= }}
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'''Solution structure of tyrosyl-tRNA synthetase C-terminal domain.'''
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===Solution structure of tyrosyl-tRNA synthetase C-terminal domain.===
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==Overview==
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The structure of a recombinant protein, TyrRS(delta4), corresponding to the anticodon arm binding domain of Bacillus stearothermophilus tyrosyl-tRNA synthetase, has been solved, and its dynamics have been studied by nuclear magnetic resonance (NMR). It is the first structure described for such a domain of a tyrosyl-tRNA synthetase. It consists of a five-stranded beta sheet, packed against two alpha helices on one side and one alpha helix on the other side. A large part of the domain is structurally similar to other functionally unrelated RNA binding proteins. The basic residues known to be essential for tRNA binding and charging are exposed to the solvent on the same face of the molecule. The structure of TyrRS(delta4), together with previous mutagenesis data, allows one to delineate the region of interaction with tRNATyr.
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The line below this paragraph, {{ABSTRACT_PUBMED_12005430}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12005430 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12005430}}
==About this Structure==
==About this Structure==
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1JH3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JH3 OCA].
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1JH3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JH3 OCA].
==Reference==
==Reference==
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[[Category: Aminoacyl-trna synthetase]]
[[Category: Aminoacyl-trna synthetase]]
[[Category: Anticodon-arm binding domain]]
[[Category: Anticodon-arm binding domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:12:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:14:07 2008''

Revision as of 17:14, 1 July 2008

Image:1jh3.png

Template:STRUCTURE 1jh3

Solution structure of tyrosyl-tRNA synthetase C-terminal domain.

Template:ABSTRACT PUBMED 12005430

About this Structure

1JH3 is a Single protein structure of sequence from Geobacillus stearothermophilus. Full experimental information is available from OCA.

Reference

Structure and dynamics of the anticodon arm binding domain of Bacillus stearothermophilus Tyrosyl-tRNA synthetase., Guijarro JI, Pintar A, Prochnicka-Chalufour A, Guez V, Gilquin B, Bedouelle H, Delepierre M, Structure. 2002 Mar;10(3):311-7. PMID:12005430

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