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1jh5

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{{STRUCTURE_1jh5| PDB=1jh5 | SCENE= }}
{{STRUCTURE_1jh5| PDB=1jh5 | SCENE= }}
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'''Crystal Structure of sTALL-1 of TNF family ligand'''
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===Crystal Structure of sTALL-1 of TNF family ligand===
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==Overview==
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TALL-1/BAFF/BLyS was recently identified as a member of the tumor necrosis factor (TNF) ligand family. The crystal structure of the functional soluble TALL-1 (sTALL-1) has been determined at 3.0 A. sTALL-1 forms a virus-like assembly with 200 A diameter in the crystals, containing 60 sTALL-1 monomers. The cluster formation is mediated by a "flap" region of the sTALL-1 monomer. The virus-like assembly was also detected in solution using gel filtration and electron microscopy. Deletion of the flap region disrupted the formation of the virus-like assembly. The mutant sTALL-1 still bound its receptor but could not activate NF-kappaB and did not stimulate B lymphocyte proliferation. Finally, we found the virus-like cluster of sTALL-1 exists in physiological condition. We propose that this virus-like assembly of sTALL-1 is the functional unit for TALL-1 in vivo.
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The line below this paragraph, {{ABSTRACT_PUBMED_11853672}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11853672 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11853672}}
==About this Structure==
==About this Structure==
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[[Category: Tall-1]]
[[Category: Tall-1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:12:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:14:14 2008''

Revision as of 17:14, 1 July 2008

Image:1jh5.png

Template:STRUCTURE 1jh5

Crystal Structure of sTALL-1 of TNF family ligand

Template:ABSTRACT PUBMED 11853672

About this Structure

1JH5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands., Liu Y, Xu L, Opalka N, Kappler J, Shu HB, Zhang G, Cell. 2002 Feb 8;108(3):383-94. PMID:11853672

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