1jhc

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[[Image:1jhc.gif|left|200px]]
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{{STRUCTURE_1jhc| PDB=1jhc | SCENE= }}
{{STRUCTURE_1jhc| PDB=1jhc | SCENE= }}
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'''LEXA S119A C-TERMINAL TRYPTIC FRAGMENT'''
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===LEXA S119A C-TERMINAL TRYPTIC FRAGMENT===
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==Overview==
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LexA repressor undergoes a self-cleavage reaction. In vivo, this reaction requires an activated form of RecA, but it occurs spontaneously in vitro at high pH. Accordingly, LexA must both allow self-cleavage and yet prevent this reaction in the absence of a stimulus. We have solved the crystal structures of several mutant forms of LexA. Strikingly, two distinct conformations are observed, one compatible with cleavage, and the other in which the cleavage site is approximately 20 A from the catalytic center. Our analysis provides insight into the structural and energetic features that modulate the interconversion between these two forms and hence the rate of the self-cleavage reaction. We suggest RecA activates the self-cleavage of LexA and related proteins through selective stabilization of the cleavable conformation.
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(as it appears on PubMed at http://www.pubmed.gov), where 11551506 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11551506}}
==About this Structure==
==About this Structure==
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[[Category: Strynadka, N C.J.]]
[[Category: Strynadka, N C.J.]]
[[Category: Lexa sos repressor]]
[[Category: Lexa sos repressor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:14:43 2008''

Revision as of 17:14, 1 July 2008

Image:1jhc.png

Template:STRUCTURE 1jhc

LEXA S119A C-TERMINAL TRYPTIC FRAGMENT

Template:ABSTRACT PUBMED 11551506

About this Structure

1JHC is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of LexA: a conformational switch for regulation of self-cleavage., Luo Y, Pfuetzner RA, Mosimann S, Paetzel M, Frey EA, Cherney M, Kim B, Little JW, Strynadka NC, Cell. 2001 Sep 7;106(5):585-94. PMID:11551506

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