1jhe

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{{STRUCTURE_1jhe| PDB=1jhe | SCENE= }}
{{STRUCTURE_1jhe| PDB=1jhe | SCENE= }}
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'''LEXA L89P Q92W E152A K156A MUTANT'''
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===LEXA L89P Q92W E152A K156A MUTANT===
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==Overview==
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LexA repressor undergoes a self-cleavage reaction. In vivo, this reaction requires an activated form of RecA, but it occurs spontaneously in vitro at high pH. Accordingly, LexA must both allow self-cleavage and yet prevent this reaction in the absence of a stimulus. We have solved the crystal structures of several mutant forms of LexA. Strikingly, two distinct conformations are observed, one compatible with cleavage, and the other in which the cleavage site is approximately 20 A from the catalytic center. Our analysis provides insight into the structural and energetic features that modulate the interconversion between these two forms and hence the rate of the self-cleavage reaction. We suggest RecA activates the self-cleavage of LexA and related proteins through selective stabilization of the cleavable conformation.
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{{ABSTRACT_PUBMED_11551506}}
==About this Structure==
==About this Structure==
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[[Category: C-terminal]]
[[Category: C-terminal]]
[[Category: Lexa sos repressor]]
[[Category: Lexa sos repressor]]
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Revision as of 17:15, 1 July 2008

Image:1jhe.png

Template:STRUCTURE 1jhe

LEXA L89P Q92W E152A K156A MUTANT

Template:ABSTRACT PUBMED 11551506

About this Structure

1JHE is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of LexA: a conformational switch for regulation of self-cleavage., Luo Y, Pfuetzner RA, Mosimann S, Paetzel M, Frey EA, Cherney M, Kim B, Little JW, Strynadka NC, Cell. 2001 Sep 7;106(5):585-94. PMID:11551506

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