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1jhj

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{{STRUCTURE_1jhj| PDB=1jhj | SCENE= }}
{{STRUCTURE_1jhj| PDB=1jhj | SCENE= }}
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'''Crystal structure of the APC10/Doc1 subunit of the human anaphase-promoting complex'''
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===Crystal structure of the APC10/Doc1 subunit of the human anaphase-promoting complex===
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==Overview==
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The anaphase-promoting complex (APC), or cyclosome, is a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC is composed of at least 11 subunits; no structure has been determined for any of these subunits. The subunit APC10/DOC1, a one-domain protein consisting of 185 amino acids, has a conserved core (residues 22-161) that is homologous to domains found in several other putative ubiquitin ligases and, therefore, may play a role in ubiquitination reactions. Here we report the crystal structure of human APC10 at 1.6 A resolution. The core of the protein is formed by a beta-sandwich that adopts a jellyroll fold. Unexpectedly, this structure is highly similar to ligand-binding domains of several bacterial and eukaryotic proteins, such as galactose oxidase and coagulation factor Va, raising the possibility that APC10 may function by binding a yet unidentified ligand. We further provide biochemical evidence that the C-terminus of APC10 binds to CDC27/APC3, an APC subunit that contains multiple tetratrico peptide repeats.
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The line below this paragraph, {{ABSTRACT_PUBMED_11524682}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11524682 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11524682}}
==About this Structure==
==About this Structure==
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[[Category: Beta sandwich]]
[[Category: Beta sandwich]]
[[Category: Jellyroll]]
[[Category: Jellyroll]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:13:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:15:17 2008''

Revision as of 17:15, 1 July 2008

Image:1jhj.png

Template:STRUCTURE 1jhj

Crystal structure of the APC10/Doc1 subunit of the human anaphase-promoting complex

Template:ABSTRACT PUBMED 11524682

About this Structure

1JHJ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the APC10/DOC1 subunit of the human anaphase-promoting complex., Wendt KS, Vodermaier HC, Jacob U, Gieffers C, Gmachl M, Peters JM, Huber R, Sondermann P, Nat Struct Biol. 2001 Sep;8(9):784-8. PMID:11524682

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