This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1ji7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1ji7.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1ji7.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1ji7| PDB=1ji7 | SCENE= }}
{{STRUCTURE_1ji7| PDB=1ji7 | SCENE= }}
-
'''Crystal Structure of TEL SAM Polymer'''
+
===Crystal Structure of TEL SAM Polymer===
-
==Overview==
+
<!--
-
TEL is a transcriptional repressor that is a frequent target of chromosomal translocations in a large number of hematalogical malignancies. These rearrangements fuse a potent oligomerization module, the SAM domain of TEL, to a variety of tyrosine kinases or transcriptional regulatory proteins. The self-associating property of TEL-SAM is essential for cell transformation in many, if not all of these diseases. Here we show that the TEL-SAM domain forms a helical, head-to-tail polymeric structure held together by strong intermolecular contacts, providing the first clear demonstration that SAM domains can polymerize. Our results also suggest a mechanism by which SAM domains could mediate the spreading of transcriptional repression complexes along the chromosome.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11483520}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11483520 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11483520}}
==Disease==
==Disease==
Line 34: Line 38:
[[Category: Tran, H H.]]
[[Category: Tran, H H.]]
[[Category: Helical polymer]]
[[Category: Helical polymer]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:15:18 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:17:00 2008''

Revision as of 17:17, 1 July 2008

Image:1ji7.png

Template:STRUCTURE 1ji7

Contents

Crystal Structure of TEL SAM Polymer

Template:ABSTRACT PUBMED 11483520

Disease

Known disease associated with this structure: Leukemia, acute myeloid, somatic OMIM:[600618]

About this Structure

1JI7 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Polymerization of the SAM domain of TEL in leukemogenesis and transcriptional repression., Kim CA, Phillips ML, Kim W, Gingery M, Tran HH, Robinson MA, Faham S, Bowie JU, EMBO J. 2001 Aug 1;20(15):4173-82. PMID:11483520

Page seeded by OCA on Tue Jul 1 20:17:00 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ji7"
Personal tools