1jid

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[[Image:1jid.jpg|left|200px]]
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{{STRUCTURE_1jid| PDB=1jid | SCENE= }}
{{STRUCTURE_1jid| PDB=1jid | SCENE= }}
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'''Human SRP19 in complex with helix 6 of Human SRP RNA'''
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===Human SRP19 in complex with helix 6 of Human SRP RNA===
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==Overview==
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The signal recognition particle (SRP) is a universally conserved ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to cellular membranes. A crucial early step in SRP assembly in archaea and eukarya is the binding of protein SRP19 to specific sites on SRP RNA. Here we report the 1.8 angstrom resolution crystal structure of human SRP19 in complex with its primary binding site on helix 6 of SRP RNA, which consists of a stem-loop structure closed by an unusual GGAG tetraloop. Protein-RNA interactions are mediated by the specific recognition of a widened major groove and the tetraloop without any direct protein-base contacts and include a complex network of highly ordered water molecules. A model of the assembly of the SRP core comprising SRP19, SRP54, and SRP RNA based on crystallographic and biochemical data is proposed.
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(as it appears on PubMed at http://www.pubmed.gov), where 11641499 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11641499}}
==About this Structure==
==About this Structure==
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[[Category: Ggag tetraloop]]
[[Category: Ggag tetraloop]]
[[Category: Protein-rna complex]]
[[Category: Protein-rna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:15:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:17:38 2008''

Revision as of 17:17, 1 July 2008

Image:1jid.png

Template:STRUCTURE 1jid

Human SRP19 in complex with helix 6 of Human SRP RNA

Template:ABSTRACT PUBMED 11641499

About this Structure

1JID is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of an early protein-RNA assembly complex of the signal recognition particle., Wild K, Sinning I, Cusack S, Science. 2001 Oct 19;294(5542):598-601. PMID:11641499

Page seeded by OCA on Tue Jul 1 20:17:38 2008

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