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1jjr

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[[Image:1jjr.gif|left|200px]]
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{{STRUCTURE_1jjr| PDB=1jjr | SCENE= }}
{{STRUCTURE_1jjr| PDB=1jjr | SCENE= }}
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'''The Three-Dimensional Structure of the C-terminal DNA Binding Domain of Human Ku70'''
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===The Three-Dimensional Structure of the C-terminal DNA Binding Domain of Human Ku70===
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==Overview==
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The proteins Ku70 (69.8 kDa) and Ku80 (82.7 kDa) form a heterodimeric complex that is an essential component of the nonhomologous end joining DNA double-strand break repair pathway in mammalian cells. Interaction of Ku with DNA is central for the functions of Ku. Ku70, which is mainly responsible for the DNA binding activity of the Ku heterodimer, contains two DNA-binding domains. We have solved the solution structure of the Ku80-independent DNA-binding domain of Ku70 encompassing residues 536-609 using nuclear magnetic resonance spectroscopy. Residues 536-560 are highly flexible and have a random structure but form specific interactions with DNA. Residues 561-609 of Ku70 form a well defined structure with 3 alpha-helices and also interact with DNA. The three-dimensional structure indicates that all conserved hydrophobic residues are in the hydrophobic core and therefore may be important for structural integrity. Most of the conserved positively charged residues are likely to be critical for DNA recognition. The C-terminal DNA-binding domain of Ku70 contains a helix-extended strand-helix motif, which occurs in other nucleic acid-binding proteins and may represent a common nucleic acid binding motif.
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(as it appears on PubMed at http://www.pubmed.gov), where 11457852 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11457852}}
==About this Structure==
==About this Structure==
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1JJR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JJR OCA].
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1JJR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JJR OCA].
==Reference==
==Reference==
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[[Category: Protein-dna interaction]]
[[Category: Protein-dna interaction]]
[[Category: Solution structure]]
[[Category: Solution structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:18:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:21:07 2008''

Revision as of 17:21, 1 July 2008

Image:1jjr.png

Template:STRUCTURE 1jjr

The Three-Dimensional Structure of the C-terminal DNA Binding Domain of Human Ku70

Template:ABSTRACT PUBMED 11457852

About this Structure

1JJR is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

The three-dimensional structure of the C-terminal DNA-binding domain of human Ku70., Zhang Z, Zhu L, Lin D, Chen F, Chen DJ, Chen Y, J Biol Chem. 2001 Oct 12;276(41):38231-6. Epub 2001 Jul 16. PMID:11457852

Page seeded by OCA on Tue Jul 1 20:21:07 2008

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