1jjx

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[[Image:1jjx.jpg|left|200px]]
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{{STRUCTURE_1jjx| PDB=1jjx | SCENE= }}
{{STRUCTURE_1jjx| PDB=1jjx | SCENE= }}
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'''Solution Structure of Recombinant Human Brain-type Fatty acid Binding Protein'''
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===Solution Structure of Recombinant Human Brain-type Fatty acid Binding Protein===
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==Overview==
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Human brain-type fatty acid-binding protein (B-FABP) has been recombinantly expressed in Escherichia coli both unlabelled and 15N-enriched for structure investigation in solution using high-resolution NMR spectroscopy. The sequential assignments of the 1H and 15N resonances were achieved by applying multidimensional homo- and heteronuclear NMR experiments. The ensemble of the 20 final energy-minimized structures, representing human B-FABP in solution, have been calculated based on a total of 2490 meaningful distance constraints. The overall B-FABP structure exhibits the typical backbone conformation described for other members of the FABP family, consisting often antiparallel beta-strands (betaA to betaJ) that form two almost orthogonal beta-sheets, a helix-turn-helix motif that closes the beta-barrel on one side, and a short N-terminal helical loop. A comparison with the crystal structure of the same protein complexed with docosahexaenoic acid reveals only minor differences in both secondary structure and overall topology. Moreover, the NMR data indicate a close structural relationship between human B-FABP and heart-type FABP with respect to fatty acid binding inside the protein cavity.
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(as it appears on PubMed at http://www.pubmed.gov), where 12479569 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12479569}}
==About this Structure==
==About this Structure==
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1JJX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JJX OCA].
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1JJX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JJX OCA].
==Reference==
==Reference==
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[[Category: Lipid binding protein]]
[[Category: Lipid binding protein]]
[[Category: Nmr spectroscopy]]
[[Category: Nmr spectroscopy]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:18:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:21:33 2008''

Revision as of 17:21, 1 July 2008

Image:1jjx.png

Template:STRUCTURE 1jjx

Solution Structure of Recombinant Human Brain-type Fatty acid Binding Protein

Template:ABSTRACT PUBMED 12479569

About this Structure

1JJX is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of fatty acid-binding protein from human brain., Rademacher M, Zimmerman AW, Ruterjans H, Veerkamp JH, Lucke C, Mol Cell Biochem. 2002 Oct;239(1-2):61-8. PMID:12479569

Page seeded by OCA on Tue Jul 1 20:21:33 2008

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