1jk9

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[[Image:1jk9.jpg|left|200px]]
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{{Seed}}
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[[Image:1jk9.png|left|200px]]
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{{STRUCTURE_1jk9| PDB=1jk9 | SCENE= }}
{{STRUCTURE_1jk9| PDB=1jk9 | SCENE= }}
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'''Heterodimer between H48F-ySOD1 and yCCS'''
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===Heterodimer between H48F-ySOD1 and yCCS===
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==Overview==
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The copper chaperone for superoxide dismutase (CCS) activates the eukaryotic antioxidant enzyme copper, zinc superoxide dismutase (SOD1). The 2.9 A resolution structure of yeast SOD1 complexed with yeast CCS (yCCS) reveals that SOD1 interacts with its metallochaperone to form a complex comprising one monomer of each protein. The heterodimer interface is remarkably similar to the SOD1 and yCCS homodimer interfaces. Striking conformational rearrangements are observed in both the chaperone and target enzyme upon complex formation, and the functionally essential C-terminal domain of yCCS is well positioned to play a key role in the metal ion transfer mechanism. This domain is linked to SOD1 by an intermolecular disulfide bond that may facilitate or regulate copper delivery.
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The line below this paragraph, {{ABSTRACT_PUBMED_11524675}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11524675 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11524675}}
==About this Structure==
==About this Structure==
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[[Category: Metallochaperone]]
[[Category: Metallochaperone]]
[[Category: Protein-protein complex]]
[[Category: Protein-protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:19:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:22:26 2008''

Revision as of 17:22, 1 July 2008

Image:1jk9.png

Template:STRUCTURE 1jk9

Heterodimer between H48F-ySOD1 and yCCS

Template:ABSTRACT PUBMED 11524675

About this Structure

1JK9 is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Heterodimeric structure of superoxide dismutase in complex with its metallochaperone., Lamb AL, Torres AS, O'Halloran TV, Rosenzweig AC, Nat Struct Biol. 2001 Sep;8(9):751-5. PMID:11524675

Page seeded by OCA on Tue Jul 1 20:22:26 2008

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