1jl3

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1jl3.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1jl3.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1jl3| PDB=1jl3 | SCENE= }}
{{STRUCTURE_1jl3| PDB=1jl3 | SCENE= }}
-
'''Crystal Structure of B. subtilis ArsC'''
+
===Crystal Structure of B. subtilis ArsC===
-
==Overview==
+
<!--
-
Arsenate is an abundant oxyanion that, because of its ability to mimic the phosphate group, is toxic to cells. Arsenate reductase (EC; encoded by the arsC gene in bacteria) participates to achieve arsenate resistance in both prokaryotes and yeast by reducing arsenate to arsenite; the arsenite is then exported by a specific transporter. The crystal structure of Bacillus subtilis arsenate reductase in the reduced form with a bound sulfate ion in its active site is solved at 1.6-A resolution. Significant structural similarity is seen between arsenate reductase and bovine low molecular weight protein tyrosine phosphatase, despite very low sequence identity. The similarity is especially high between their active sites. It is further confirmed that this structural homology is relevant functionally by showing the phosphatase activity of the arsenate reductase in vitro. Thus, we can understand the arsenate reduction in the light of low molecular weight protein tyrosine phosphatase mechanism and also explain the catalytic roles of essential residues such as Cys-10, Cys-82, Cys-89, Arg-16, and Asp-105. A "triple cysteine redox relay" is proposed for the arsenate reduction mechanism.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11698660}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11698660 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11698660}}
==About this Structure==
==About this Structure==
Line 27: Line 31:
[[Category: Arsenate reductase]]
[[Category: Arsenate reductase]]
[[Category: Ptp-loop]]
[[Category: Ptp-loop]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:21:20 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:24:44 2008''

Revision as of 17:24, 1 July 2008

Image:1jl3.png

Template:STRUCTURE 1jl3

Crystal Structure of B. subtilis ArsC

Template:ABSTRACT PUBMED 11698660

About this Structure

1JL3 is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

Bacillus subtilis arsenate reductase is structurally and functionally similar to low molecular weight protein tyrosine phosphatases., Bennett MS, Guan Z, Laurberg M, Su XD, Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13577-82. Epub 2001 Nov 6. PMID:11698660

Page seeded by OCA on Tue Jul 1 20:24:44 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1jl3"
Personal tools