1jlv

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[[Image:1jlv.gif|left|200px]]
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{{STRUCTURE_1jlv| PDB=1jlv | SCENE= }}
{{STRUCTURE_1jlv| PDB=1jlv | SCENE= }}
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'''Anopheles dirus species B glutathione S-transferases 1-3'''
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===Anopheles dirus species B glutathione S-transferases 1-3===
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==Overview==
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Glutathione S-transferases (GSTs) are dimeric proteins that play an important role in cellular detoxification. Four GSTs from the mosquito Anopheles dirus species B (Ad), an important malaria vector in South East Asia, are produced by alternate splicing of a single transcription product and were previously shown to have detoxifying activity towards pesticides such as DDT. We have determined the crystal structures for two of these alternatively spliced proteins, AdGST1-3 (complexed with glutathione) and AdGST1-4 (apo form), at 1.75 and 2.45 A resolution, respectively. These GST isozymes show differences from the related GST from the Australian sheep blowfly Lucilia cuprina; in particular, the presence of a C-terminal helix forming part of the active site. This helix causes the active site of the Anopheles GSTs to be enclosed. The glutathione-binding helix alpha2 and flanking residues are disordered in the AdGST1-4 (apo) structure, yet ordered in the AdGST1-3 (GSH-bound) structure, suggesting that insect GSTs operate with an induced fit mechanism similar to that found in the plant phi- and human pi-class GSTs. Despite the high overall sequence identities, the active site residues of AdGST1-4 and AdGST1-3 have different conformations.
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The line below this paragraph, {{ABSTRACT_PUBMED_11604524}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11604524 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11604524}}
==About this Structure==
==About this Structure==
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[[Category: Glutathione s-transferase]]
[[Category: Glutathione s-transferase]]
[[Category: Gst]]
[[Category: Gst]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:23:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:26:49 2008''

Revision as of 17:26, 1 July 2008

Image:1jlv.png

Template:STRUCTURE 1jlv

Anopheles dirus species B glutathione S-transferases 1-3

Template:ABSTRACT PUBMED 11604524

About this Structure

1JLV is a Single protein structure of sequence from Anopheles cracens. Full crystallographic information is available from OCA.

Reference

The crystal structures of glutathione S-transferases isozymes 1-3 and 1-4 from Anopheles dirus species B., Oakley AJ, Harnnoi T, Udomsinprasert R, Jirajaroenrat K, Ketterman AJ, Wilce MC, Protein Sci. 2001 Nov;10(11):2176-85. PMID:11604524

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