1jm4

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[[Image:1jm4.gif|left|200px]]
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{{STRUCTURE_1jm4| PDB=1jm4 | SCENE= }}
{{STRUCTURE_1jm4| PDB=1jm4 | SCENE= }}
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'''NMR Structure of P/CAF Bromodomain in Complex with HIV-1 Tat Peptide'''
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===NMR Structure of P/CAF Bromodomain in Complex with HIV-1 Tat Peptide===
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==Overview==
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The human immunodeficiency virus type 1 (HIV-1) trans-activator protein Tat stimulates transcription of the integrated HIV-1 genome and promotes viral replication in infected cells. Tat transactivation activity is dependent on lysine acetylation and its association with nuclear histone acetyltransferases p300/CBP (CREB binding protein) and p300/CBP-associated factor (PCAF). Here, we show that the bromodomain of PCAF binds specifically to HIV-1 Tat acetylated at lysine 50 and that this interaction competes effectively against HIV-1 TAR RNA binding to the lysine-acetylated Tat. The three-dimensional solution structure of the PCAF bromodomain in complex with a lysine 50-acetylated Tat peptide together with biochemical analyses provides the structural basis for the specificity of this molecular recognition and reveals insights into the differences in ligand selectivity of bromodomains.
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(as it appears on PubMed at http://www.pubmed.gov), where 11931765 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11931765}}
==About this Structure==
==About this Structure==
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1JM4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JM4 OCA].
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1JM4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JM4 OCA].
==Reference==
==Reference==
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[[Category: Bromodomain]]
[[Category: Bromodomain]]
[[Category: Protein-peptide complex]]
[[Category: Protein-peptide complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:23:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:27:27 2008''

Revision as of 17:27, 1 July 2008

Image:1jm4.png

Template:STRUCTURE 1jm4

NMR Structure of P/CAF Bromodomain in Complex with HIV-1 Tat Peptide

Template:ABSTRACT PUBMED 11931765

About this Structure

1JM4 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain., Mujtaba S, He Y, Zeng L, Farooq A, Carlson JE, Ott M, Verdin E, Zhou MM, Mol Cell. 2002 Mar;9(3):575-86. PMID:11931765

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