1jm6

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{{STRUCTURE_1jm6| PDB=1jm6 | SCENE= }}
{{STRUCTURE_1jm6| PDB=1jm6 | SCENE= }}
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'''Pyruvate dehydrogenase kinase, isozyme 2, containing ADP'''
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===Pyruvate dehydrogenase kinase, isozyme 2, containing ADP===
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==Overview==
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The structure of mitochondrial pyruvate dehydrogenase kinase isozyme 2 is of interest because it represents a family of serine-specific protein kinases that lack sequence similarity with all other eukaryotic protein kinases. Similarity exists instead with key motifs of prokaryotic histidine protein kinases and a family of eukaryotic ATPases. The 2.5-A crystal structure reported here reveals that pyruvate dehydrogenase kinase isozyme 2 has two domains of about the same size. The N-terminal half is dominated by a bundle of four amphipathic alpha-helices, whereas the C-terminal half is folded into an alpha/beta sandwich that contains the nucleotide-binding site. Analysis of the structure reveals this C-terminal domain to be very similar to the nucleotide-binding domain of bacterial histidine kinases, but the catalytic mechanism appears similar to that of the eukaryotic serine kinases and ATPases.
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(as it appears on PubMed at http://www.pubmed.gov), where 11483605 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11483605}}
==About this Structure==
==About this Structure==
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[[Category: Mitochondion]]
[[Category: Mitochondion]]
[[Category: Serine kinase]]
[[Category: Serine kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:27:30 2008''

Revision as of 17:27, 1 July 2008

Image:1jm6.png

Template:STRUCTURE 1jm6

Pyruvate dehydrogenase kinase, isozyme 2, containing ADP

Template:ABSTRACT PUBMED 11483605

About this Structure

1JM6 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structure of pyruvate dehydrogenase kinase. Novel folding pattern for a serine protein kinase., Steussy CN, Popov KM, Bowker-Kinley MM, Sloan RB Jr, Harris RA, Hamilton JA, J Biol Chem. 2001 Oct 5;276(40):37443-50. Epub 2001 Aug 1. PMID:11483605

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