1jm7

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[[Image:1jm7.gif|left|200px]]
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[[Image:1jm7.png|left|200px]]
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{{STRUCTURE_1jm7| PDB=1jm7 | SCENE= }}
{{STRUCTURE_1jm7| PDB=1jm7 | SCENE= }}
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'''Solution structure of the BRCA1/BARD1 RING-domain heterodimer'''
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===Solution structure of the BRCA1/BARD1 RING-domain heterodimer===
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==Overview==
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The RING domain of the breast and ovarian cancer tumor suppressor BRCA1 interacts with multiple cognate proteins, including the RING protein BARD1. Proper function of the BRCA1 RING domain is critical, as evidenced by the many cancer-predisposing mutations found within this domain. We present the solution structure of the heterodimer formed between the RING domains of BRCA1 and BARD1. Comparison with the RING homodimer of the V(D)J recombination-activating protein RAG1 reveals the structural diversity of complexes formed by interactions between different RING domains. The BRCA1-BARD1 structure provides a model for its ubiquitin ligase activity, illustrates how the BRCA1 RING domain can be involved in associations with multiple protein partners and provides a framework for understanding cancer-causing mutations at the molecular level.
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(as it appears on PubMed at http://www.pubmed.gov), where 11573085 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11573085}}
==Disease==
==Disease==
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==About this Structure==
==About this Structure==
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1JM7 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JM7 OCA].
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1JM7 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JM7 OCA].
==Reference==
==Reference==
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[[Category: Ubiquitin ligase]]
[[Category: Ubiquitin ligase]]
[[Category: Zinc-binding protein]]
[[Category: Zinc-binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:23:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:27:37 2008''

Revision as of 17:27, 1 July 2008

Image:1jm7.png

Template:STRUCTURE 1jm7

Contents

Solution structure of the BRCA1/BARD1 RING-domain heterodimer

Template:ABSTRACT PUBMED 11573085

Disease

Known disease associated with this structure: Breast cancer-1 OMIM:[113705], Breast-ovarian cancer OMIM:[113705], Ovarian cancer OMIM:[113705], Papillary serous carcinoma of the peritoneum OMIM:[113705], Breast cancer, susceptibility to OMIM:[601593]

About this Structure

1JM7 is a Protein complex structure of sequences from Homo sapiens. Full experimental information is available from OCA.

Reference

Structure of a BRCA1-BARD1 heterodimeric RING-RING complex., Brzovic PS, Rajagopal P, Hoyt DW, King MC, Klevit RE, Nat Struct Biol. 2001 Oct;8(10):833-7. PMID:11573085

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