1jma

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{{STRUCTURE_1jma| PDB=1jma | SCENE= }}
{{STRUCTURE_1jma| PDB=1jma | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE HERPES SIMPLEX VIRUS GLYCOPROTEIN D BOUND TO THE CELLULAR RECEPTOR HVEA/HVEM'''
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===CRYSTAL STRUCTURE OF THE HERPES SIMPLEX VIRUS GLYCOPROTEIN D BOUND TO THE CELLULAR RECEPTOR HVEA/HVEM===
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==Overview==
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Herpes simplex virus (HSV) infection requires binding of the viral envelope glycoprotein D (gD) to cell surface receptors. We report the X-ray structures of a soluble, truncated ectodomain of gD both alone and in complex with the ectodomain of its cellular receptor HveA. Two bound anions suggest possible binding sites for another gD receptor, a 3-O-sulfonated heparan sulfate. Unexpectedly, the structures reveal a V-like immunoglobulin (Ig) fold at the core of gD that is closely related to cellular adhesion molecules and flanked by large N- and C-terminal extensions. The receptor binding segment of gD, an N-terminal hairpin, appears conformationally flexible, suggesting that a conformational change accompanying binding might be part of the viral entry mechanism.
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(as it appears on PubMed at http://www.pubmed.gov), where 11511370 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11511370}}
==About this Structure==
==About this Structure==
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[[Category: Willis, S H.]]
[[Category: Willis, S H.]]
[[Category: V-type ig molecule and tnfr superfamily]]
[[Category: V-type ig molecule and tnfr superfamily]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:24:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:27:42 2008''

Revision as of 17:27, 1 July 2008

Image:1jma.png

Template:STRUCTURE 1jma

CRYSTAL STRUCTURE OF THE HERPES SIMPLEX VIRUS GLYCOPROTEIN D BOUND TO THE CELLULAR RECEPTOR HVEA/HVEM

Template:ABSTRACT PUBMED 11511370

About this Structure

1JMA is a Protein complex structure of sequences from Homo sapiens and Human herpesvirus 1. Full crystallographic information is available from OCA.

Reference

Herpes simplex virus glycoprotein D bound to the human receptor HveA., Carfi A, Willis SH, Whitbeck JC, Krummenacher C, Cohen GH, Eisenberg RJ, Wiley DC, Mol Cell. 2001 Jul;8(1):169-79. PMID:11511370

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