1jmc

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{{STRUCTURE_1jmc| PDB=1jmc | SCENE= }}
{{STRUCTURE_1jmc| PDB=1jmc | SCENE= }}
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'''SINGLE STRANDED DNA-BINDING DOMAIN OF HUMAN REPLICATION PROTEIN A BOUND TO SINGLE STRANDED DNA, RPA70 SUBUNIT, RESIDUES 183-420'''
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===SINGLE STRANDED DNA-BINDING DOMAIN OF HUMAN REPLICATION PROTEIN A BOUND TO SINGLE STRANDED DNA, RPA70 SUBUNIT, RESIDUES 183-420===
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==Overview==
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The single-stranded-DNA-binding proteins (SSBs) are essential for DNA function in prokaryotic and eukaryotic cells, mitochondria, phages and viruses. The structures of four SSBs have been solved, but the molecular details of the interaction of SSBs with DNA remain speculative. We report here the crystal structure at 2.4 A resolution of the single-stranded-DNA-binding domain of human replication protein A (RPA) bound to DNA. Replication protein A is a heterotrimeric SSB that is highly conserved in eukaryotes. The largest subunit, RPA70, binds to single-stranded (ss)DNA and mediates interactions with many cellular and viral proteins. The DNA-binding domain, which lies in the middle of RPA70, comprises two structurally homologous subdomains oriented in tandem. The ssDNA lies in a channel that extends from one subdomain to the other. The structure of each RPA70 subdomain is similar to those of the bacteriophage SSBs, indicating that the mechanism of ssDNA-binding is conserved.
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{{ABSTRACT_PUBMED_8990123}}
==About this Structure==
==About this Structure==
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[[Category: Protein-ssdna complex]]
[[Category: Protein-ssdna complex]]
[[Category: Single stranded dna-binding protein]]
[[Category: Single stranded dna-binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:27:52 2008''

Revision as of 17:27, 1 July 2008

Image:1jmc.png

Template:STRUCTURE 1jmc

SINGLE STRANDED DNA-BINDING DOMAIN OF HUMAN REPLICATION PROTEIN A BOUND TO SINGLE STRANDED DNA, RPA70 SUBUNIT, RESIDUES 183-420

Template:ABSTRACT PUBMED 8990123

About this Structure

1JMC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the single-stranded-DNA-binding domain of replication protein A bound to DNA., Bochkarev A, Pfuetzner RA, Edwards AM, Frappier L, Nature. 1997 Jan 9;385(6612):176-81. PMID:8990123

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