1jmx

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[[Image:1jmx.jpg|left|200px]]
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{{Seed}}
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[[Image:1jmx.png|left|200px]]
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{{STRUCTURE_1jmx| PDB=1jmx | SCENE= }}
{{STRUCTURE_1jmx| PDB=1jmx | SCENE= }}
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'''crystal structure of a quinohemoprotein amine dehydrogenase from pseudomonas putida'''
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===crystal structure of a quinohemoprotein amine dehydrogenase from pseudomonas putida===
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==Overview==
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The crystal structure of a quinohemoprotein amine dehydrogenase from Pseudomonas putida has been determined at 1.9-A resolution. The enzyme comprises three non-identical subunits: a four-domain alpha-subunit that harbors a di-heme cytochrome c, a seven-bladed beta-propeller beta-subunit that provides part of the active site, and a small gamma-subunit that contains a novel cross-linked, proteinous quinone cofactor, cysteine tryptophylquinone. More surprisingly, the catalytic gamma-subunit contains three additional chemical cross-links that encage the cysteine tryptophylquinone cofactor, involving a cysteine side chain bridged to either an Asp or Glu residue all in a hitherto unknown thioether bonding with a methylene carbon atom of acidic amino acid side chains. Thus, the structure of the 79-residue gamma-subunit is quite unusual, containing four internal cross-links in such a short polypeptide chain that would otherwise be difficult to fold into a globular structure.
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The line below this paragraph, {{ABSTRACT_PUBMED_11704672}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11704672 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11704672}}
==About this Structure==
==About this Structure==
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[[Category: Satoh, A.]]
[[Category: Satoh, A.]]
[[Category: Amine dehydrogenase]]
[[Category: Amine dehydrogenase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:25:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:29:17 2008''

Revision as of 17:29, 1 July 2008

Image:1jmx.png

Template:STRUCTURE 1jmx

crystal structure of a quinohemoprotein amine dehydrogenase from pseudomonas putida

Template:ABSTRACT PUBMED 11704672

About this Structure

1JMX is a Protein complex structure of sequences from Pseudomonas putida. Full crystallographic information is available from OCA.

Reference

Crystal structure of quinohemoprotein amine dehydrogenase from Pseudomonas putida. Identification of a novel quinone cofactor encaged by multiple thioether cross-bridges., Satoh A, Kim JK, Miyahara I, Devreese B, Vandenberghe I, Hacisalihoglu A, Okajima T, Kuroda S, Adachi O, Duine JA, Van Beeumen J, Tanizawa K, Hirotsu K, J Biol Chem. 2002 Jan 25;277(4):2830-4. Epub 2001 Nov 9. PMID:11704672

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