1jnp

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[[Image:1jnp.jpg|left|200px]]
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{{STRUCTURE_1jnp| PDB=1jnp | SCENE= }}
{{STRUCTURE_1jnp| PDB=1jnp | SCENE= }}
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'''Crystal Structure of Murine Tcl1 at 2.5 Resolution'''
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===Crystal Structure of Murine Tcl1 at 2.5 Resolution===
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==Overview==
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Tcl1 and Mtcp1, members of the Tcl1 family, are implicated in T-cell prolymphocytic leukemia. The crystal structure of a dimer of murine Tcl1 has been determined at 2.5 A resolution with an R factor of 0.225. Murine Tcl1, human Tcl1 and Mtcp1 share very similar subunit structures, with RMS differences of 0.6 and 1.4 A for C(alpha) atoms, respectively, while the sequences share 50 and 36% identity, respectively. These structures fold into an eight-stranded beta-barrel of unique topology and high internal symmetry of 1.1-1.3 A for the two halves of human and murine Tcl1 and 1.7 A for Mtcp1, despite the low 12-13% sequence identity. The molecular surfaces of all three structures showed a common planar region which is likely to be involved in protein-protein interactions.
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(as it appears on PubMed at http://www.pubmed.gov), where 11679718 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11679718}}
==About this Structure==
==About this Structure==
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[[Category: Beta barrel]]
[[Category: Beta barrel]]
[[Category: Dimer]]
[[Category: Dimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:27:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:31:09 2008''

Revision as of 17:31, 1 July 2008

Image:1jnp.png

Template:STRUCTURE 1jnp

Crystal Structure of Murine Tcl1 at 2.5 Resolution

Template:ABSTRACT PUBMED 11679718

About this Structure

1JNP is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure of murine Tcl1 at 2.5 A resolution and implications for the TCL oncogene family., Petock JM, Torshin IY, Wang YF, Du Bois GC, Croce CM, Harrison RW, Weber IT, Acta Crystallogr D Biol Crystallogr. 2001 Nov;57(Pt 11):1545-51. Epub 2001, Oct 25. PMID:11679718

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