1jof

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1jof.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1jof.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1jof| PDB=1jof | SCENE= }}
{{STRUCTURE_1jof| PDB=1jof | SCENE= }}
-
'''Neurospora crassa 3-carboxy-cis,cis-mucoante lactonizing enzyme'''
+
===Neurospora crassa 3-carboxy-cis,cis-mucoante lactonizing enzyme===
-
==Overview==
+
<!--
-
Muconate lactonizing enzymes (MLEs) convert cis,cis-muconates to muconolactones in microbes as part of the beta-ketoadipate pathway; some also dehalogenate muconate derivatives of xenobiotic haloaromatics. There are three different MLE classes unrelated by evolution. We present the X-ray structure of a eukaryotic MLE, Neurospora crassa 3-carboxy-cis,cis-muconate lactonizing enzyme (NcCMLE) at 2.5 A resolution, with a seven-bladed beta propeller fold. It is related neither to bacterial MLEs nor to other beta propeller enzymes, but is structurally similar to the G protein beta subunit. It reveals a novel metal-independent cycloisomerase motif unlike the bacterial metal cofactor MLEs. Together, the bacterial MLEs and NcCMLE structures comprise a striking structural example of functional convergence in enzymes for 1,2-addition-elimination of carboxylic acids. NcCMLE and bacterial MLEs may enhance the reaction rate differently: the former by electrophilic catalysis and the latter by electrostatic stabilization of the enolate.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11937053}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11937053 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11937053}}
==About this Structure==
==About this Structure==
Line 33: Line 37:
[[Category: Homotetramer]]
[[Category: Homotetramer]]
[[Category: Semet-protein]]
[[Category: Semet-protein]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:30:12 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:33:16 2008''

Revision as of 17:33, 1 July 2008

Image:1jof.png

Template:STRUCTURE 1jof

Neurospora crassa 3-carboxy-cis,cis-mucoante lactonizing enzyme

Template:ABSTRACT PUBMED 11937053

About this Structure

1JOF is a Single protein structure of sequence from Neurospora crassa. Full crystallographic information is available from OCA.

Reference

The structure of Neurospora crassa 3-carboxy-cis,cis-muconate lactonizing enzyme, a beta propeller cycloisomerase., Kajander T, Merckel MC, Thompson A, Deacon AM, Mazur P, Kozarich JW, Goldman A, Structure. 2002 Apr;10(4):483-92. PMID:11937053

Page seeded by OCA on Tue Jul 1 20:33:16 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1jof"
Personal tools