1joy

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{{STRUCTURE_1joy| PDB=1joy | SCENE= }}
{{STRUCTURE_1joy| PDB=1joy | SCENE= }}
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'''SOLUTION STRUCTURE OF THE HOMODIMERIC DOMAIN OF ENVZ FROM ESCHERICHIA COLI BY MULTI-DIMENSIONAL NMR.'''
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===SOLUTION STRUCTURE OF THE HOMODIMERIC DOMAIN OF ENVZ FROM ESCHERICHIA COLI BY MULTI-DIMENSIONAL NMR.===
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==Overview==
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Escherichia coli osmosensor EnvZ is a protein histidine kinase that plays a central role in osmoregulation, a cellular adaptation process involving the His-Asp phosphorelay signal transduction system. Dimerization of the transmembrane protein is essential for its autophosphorylation and phosphorelay signal transduction functions. Here we present the NMR-derived structure of the homodimeric core domain (residues 223-289) of EnvZ that includes His 243, the site of autophosphorylation and phosphate transfer reactions. The structure comprises a four-helix bundle formed by two identical helix-turn-helix subunits, revealing the molecular assembly of two active sites within the dimeric kinase.
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(as it appears on PubMed at http://www.pubmed.gov), where 10426948 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10426948}}
==About this Structure==
==About this Structure==
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1JOY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JOY OCA].
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1JOY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JOY OCA].
==Reference==
==Reference==
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[[Category: Phosphorylation]]
[[Category: Phosphorylation]]
[[Category: Sensory transduction]]
[[Category: Sensory transduction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:31:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:34:43 2008''

Revision as of 17:34, 1 July 2008

Template:STRUCTURE 1joy

SOLUTION STRUCTURE OF THE HOMODIMERIC DOMAIN OF ENVZ FROM ESCHERICHIA COLI BY MULTI-DIMENSIONAL NMR.

Template:ABSTRACT PUBMED 10426948

About this Structure

1JOY is a Single protein structure of sequence from Escherichia coli. Full experimental information is available from OCA.

Reference

Solution structure of the homodimeric core domain of Escherichia coli histidine kinase EnvZ., Tomomori C, Tanaka T, Dutta R, Park H, Saha SK, Zhu Y, Ishima R, Liu D, Tong KI, Kurokawa H, Qian H, Inouye M, Ikura M, Nat Struct Biol. 1999 Aug;6(8):729-34. PMID:10426948

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