1jpl

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{{Seed}}
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{{STRUCTURE_1jpl| PDB=1jpl | SCENE= }}
{{STRUCTURE_1jpl| PDB=1jpl | SCENE= }}
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'''GGA3 VHS domain complexed with C-terminal peptide from cation-independent mannose 6-phosphate receptor'''
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===GGA3 VHS domain complexed with C-terminal peptide from cation-independent mannose 6-phosphate receptor===
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==Overview==
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Specific sorting signals direct transmembrane proteins to the compartments of the endosomal-lysosomal system. Acidic-cluster-dileucine signals present within the cytoplasmic tails of sorting receptors, such as the cation-independent and cation-dependent mannose-6-phosphate receptors, are recognized by the GGA (Golgi-localized, gamma-ear-containing, ADP-ribosylation-factor-binding) proteins. The VHS (Vps27p, Hrs and STAM) domains of the GGA proteins are responsible for the highly specific recognition of these acidic-cluster-dileucine signals. Here we report the structures of the VHS domain of human GGA3 complexed with signals from both mannose-6-phosphate receptors. The signals bind in an extended conformation to helices 6 and 8 of the VHS domain. The structures highlight an Asp residue separated by two residues from a dileucine sequence as critical recognition elements. The side chains of the Asp-X-X-Leu-Leu sequence interact with subsites consisting of one electropositive and two shallow hydrophobic pockets, respectively. The rigid spatial alignment of the three binding subsites leads to high specificity.
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(as it appears on PubMed at http://www.pubmed.gov), where 11859375 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11859375}}
==About this Structure==
==About this Structure==
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[[Category: Protein-peptide complex]]
[[Category: Protein-peptide complex]]
[[Category: Vhs domain]]
[[Category: Vhs domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:33:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:36:13 2008''

Revision as of 17:36, 1 July 2008

Image:1jpl.png

Template:STRUCTURE 1jpl

GGA3 VHS domain complexed with C-terminal peptide from cation-independent mannose 6-phosphate receptor

Template:ABSTRACT PUBMED 11859375

About this Structure

1JPL is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for acidic-cluster-dileucine sorting-signal recognition by VHS domains., Misra S, Puertollano R, Kato Y, Bonifacino JS, Hurley JH, Nature. 2002 Feb 21;415(6874):933-7. PMID:11859375

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