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1jpw

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[[Image:1jpw.jpg|left|200px]]
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{{STRUCTURE_1jpw| PDB=1jpw | SCENE= }}
{{STRUCTURE_1jpw| PDB=1jpw | SCENE= }}
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'''Crystal Structure of a Human Tcf-4 / beta-Catenin Complex'''
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===Crystal Structure of a Human Tcf-4 / beta-Catenin Complex===
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==Overview==
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The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins, and the Wnt signal transduction pathway, where it interacts with the Adenomatous polyposis coli (APC) protein and TCF/Lef family transcription factors. Mutations in APC or in beta-catenin are estimated to trigger formation of over 90% of all colon cancers. In colonic epithelia, these mutations produce elevated levels of Tcf4-beta-catenin, which stimulates a transcriptional response that initiates polyp formation and eventually malignant growth. Thus, disruption of the Tcf4-beta-catenin interaction may be an attractive goal for therapeutic intervention. Here we describe the crystal structure of a human Tcf4-beta-catenin complex and compare it with recent structures of beta-catenin in complex with Xenopus Tcf3 (XTcf3) and mammalian E-cadherin. The structure reveals anticipated similarities with the closely related XTcf3 complex but unexpectedly lacks one component observed in the XTcf3 structure.
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The line below this paragraph, {{ABSTRACT_PUBMED_11713476}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11713476 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11713476}}
==About this Structure==
==About this Structure==
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[[Category: Tcf4]]
[[Category: Tcf4]]
[[Category: Transcription factor]]
[[Category: Transcription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:34:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:37:03 2008''

Revision as of 17:37, 1 July 2008

Image:1jpw.png

Template:STRUCTURE 1jpw

Crystal Structure of a Human Tcf-4 / beta-Catenin Complex

Template:ABSTRACT PUBMED 11713476

About this Structure

1JPW is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of a human Tcf4-beta-catenin complex., Poy F, Lepourcelet M, Shivdasani RA, Eck MJ, Nat Struct Biol. 2001 Dec;8(12):1053-7. PMID:11713476

Page seeded by OCA on Tue Jul 1 20:37:03 2008

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