1jqk

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[[Image:1jqk.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1jqk| PDB=1jqk | SCENE= }}
{{STRUCTURE_1jqk| PDB=1jqk | SCENE= }}
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'''Crystal structure of carbon monoxide dehydrogenase from Rhodospirillum rubrum'''
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===Crystal structure of carbon monoxide dehydrogenase from Rhodospirillum rubrum===
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==Overview==
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A crystal structure of the anaerobic Ni-Fe-S carbon monoxide dehydrogenase (CODH) from Rhodospirillum rubrum has been determined to 2.8-A resolution. The CODH family, for which the R. rubrum enzyme is the prototype, catalyzes the biological oxidation of CO at an unusual Ni-Fe-S cluster called the C-cluster. The Ni-Fe-S C-cluster contains a mononuclear site and a four-metal cubane. Surprisingly, anomalous dispersion data suggest that the mononuclear site contains Fe and not Ni, and the four-metal cubane has the form [NiFe(3)S(4)] and not [Fe(4)S(4)]. The mononuclear site and the four-metal cluster are bridged by means of Cys(531) and one of the sulfides of the cube. CODH is organized as a dimer with a previously unidentified [Fe(4)S(4)] cluster bridging the two subunits. Each monomer is comprised of three domains: a helical domain at the N terminus, an alpha/beta (Rossmann-like) domain in the middle, and an alpha/beta (Rossmann-like) domain at the C terminus. The helical domain contributes ligands to the bridging [Fe(4)S(4)] cluster and another [Fe(4)S(4)] cluster, the B-cluster, which is involved in electron transfer. The two Rossmann domains contribute ligands to the active site C-cluster. This x-ray structure provides insight into the mechanism of biological CO oxidation and has broader significance for the roles of Ni and Fe in biological systems.
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The line below this paragraph, {{ABSTRACT_PUBMED_11593006}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11593006 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11593006}}
==About this Structure==
==About this Structure==
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[[Category: Sintchak, M D.]]
[[Category: Sintchak, M D.]]
[[Category: Rossmann fold]]
[[Category: Rossmann fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:39:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:39:03 2008''

Revision as of 17:39, 1 July 2008

Image:1jqk.png

Template:STRUCTURE 1jqk

Crystal structure of carbon monoxide dehydrogenase from Rhodospirillum rubrum

Template:ABSTRACT PUBMED 11593006

About this Structure

1JQK is a Single protein structure of sequence from Rhodospirillum rubrum. Full crystallographic information is available from OCA.

Reference

Life on carbon monoxide: X-ray structure of Rhodospirillum rubrum Ni-Fe-S carbon monoxide dehydrogenase., Drennan CL, Heo J, Sintchak MD, Schreiter E, Ludden PW, Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):11973-8. Epub 2001 Oct 2. PMID:11593006

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