1jqr

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{{STRUCTURE_1jqr| PDB=1jqr | SCENE= }}
{{STRUCTURE_1jqr| PDB=1jqr | SCENE= }}
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'''NMR structure of the African swine fever virus DNA polymerase X'''
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===NMR structure of the African swine fever virus DNA polymerase X===
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==Overview==
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The African swine fever virus DNA polymerase X (ASFV Pol X or Pol X), the smallest known nucleotide polymerase, has recently been reported to be an extremely low fidelity polymerase that may be involved in strategic mutagenesis of the viral genome. Here we report the solution structure of Pol X. The structure, unique within the realm of nucleotide polymerases, consists of only palm and fingers subdomains. Despite the absence of a thumb subdomain, which is important for DNA binding in other polymerases, we show that Pol X binds DNA with very high affinity. Further structural analyses suggest a novel mode of DNA binding that may contribute to low fidelity synthesis. We also demonstrate that the ASFV DNA ligase is a low fidelity ligase capable of sealing a nick that contains a G-G mismatch. This supports the hypothesis of a virus-encoded, mutagenic base excision repair pathway consisting of a tandem Pol X/ligase mutator.
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(as it appears on PubMed at http://www.pubmed.gov), where 11685239 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11685239}}
==About this Structure==
==About this Structure==
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1JQR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/African_swine_fever_virus African swine fever virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JQR OCA].
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1JQR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/African_swine_fever_virus African swine fever virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JQR OCA].
==Reference==
==Reference==
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[[Category: Tsai, M D.]]
[[Category: Tsai, M D.]]
[[Category: Dna polymerase]]
[[Category: Dna polymerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:41:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:39:31 2008''

Revision as of 17:39, 1 July 2008

Image:1jqr.png

Template:STRUCTURE 1jqr

NMR structure of the African swine fever virus DNA polymerase X

Template:ABSTRACT PUBMED 11685239

About this Structure

1JQR is a Single protein structure of sequence from African swine fever virus. Full experimental information is available from OCA.

Reference

Solution structure of a viral DNA polymerase X and evidence for a mutagenic function., Showalter AK, Byeon IJ, Su MI, Tsai MD, Nat Struct Biol. 2001 Nov;8(11):942-6. PMID:11685239

Page seeded by OCA on Tue Jul 1 20:39:31 2008

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