1jr3

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{{STRUCTURE_1jr3| PDB=1jr3 | SCENE= }}
{{STRUCTURE_1jr3| PDB=1jr3 | SCENE= }}
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'''Crystal Structure of the Processivity Clamp Loader Gamma Complex of E. coli DNA Polymerase III'''
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===Crystal Structure of the Processivity Clamp Loader Gamma Complex of E. coli DNA Polymerase III===
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==Overview==
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The gamma complex, an AAA+ ATPase, is the bacterial homolog of eukaryotic replication factor C (RFC) that loads the sliding clamp (beta, homologous to PCNA) onto DNA. The 2.7/3.0 A crystal structure of gamma complex reveals a pentameric arrangement of subunits, with stoichiometry delta':gamma(3):delta. The C-terminal domains of the subunits form a circular collar that supports an asymmetric arrangement of the N-terminal ATP binding domains of the gamma motor and the structurally related domains of the delta' stator and the delta wrench. The structure suggests a mechanism by which the gamma complex switches between a closed state, in which the beta-interacting element of delta is hidden by delta', and an open form similar to the crystal structure, in which delta is free to bind to beta.
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(as it appears on PubMed at http://www.pubmed.gov), where 11525729 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11525729}}
==About this Structure==
==About this Structure==
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[[Category: Processivity]]
[[Category: Processivity]]
[[Category: Processivity clamp]]
[[Category: Processivity clamp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:40:28 2008''

Revision as of 17:40, 1 July 2008

Image:1jr3.png

Template:STRUCTURE 1jr3

Crystal Structure of the Processivity Clamp Loader Gamma Complex of E. coli DNA Polymerase III

Template:ABSTRACT PUBMED 11525729

About this Structure

1JR3 is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of the processivity clamp loader gamma (gamma) complex of E. coli DNA polymerase III., Jeruzalmi D, O'Donnell M, Kuriyan J, Cell. 2001 Aug 24;106(4):429-41. PMID:11525729

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