1hf2
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(New page: 200px<br /><applet load="1hf2" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hf2, resolution 2.2Å" /> '''CRYSTAL STRUCTURE OF ...)
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Revision as of 14:26, 20 November 2007
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CRYSTAL STRUCTURE OF THE BACTERIAL CELL-DIVISION INHIBITOR MINC FROM T. MARITIMA
Overview
Bacterial cell division requires accurate selection of the middle of the, cell, where the bacterial tubulin homologue FtsZ polymerizes into a ring, structure. In Escherichia coli, site selection is dependent on MinC, MinD, and MINE: MinC acts, with MinD, to inhibit division at sites other than, the midcell by directly interacting with FTSZ: Here we report the crystal, structure to 2.2 A of MinC from Thermotoga maritima. MinC consists of two, domains separated by a short linker. The C-terminal domain is a, right-handed beta-helix and is involved in dimer formation. The crystals, contain two different MinC dimers, demonstrating flexibility in the linker, region. The two-domain architecture and dimerization of MinC can be, rationalized with a model of cell division inhibition. MinC does not act, like SulA, which affects the GTPase activity of FtsZ, and the model can, explain how MinC would select for the FtsZ polymer rather than the, monomer.
About this Structure
1HF2 is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.
Reference
Crystal structure of the bacterial cell division inhibitor MinC., Cordell SC, Anderson RE, Lowe J, EMBO J. 2001 May 15;20(10):2454-61. PMID:11350934
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