1jrf

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{{STRUCTURE_1jrf| PDB=1jrf | SCENE= }}
{{STRUCTURE_1jrf| PDB=1jrf | SCENE= }}
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'''NMR Solution Structure of the Viral Receptor Domain of Tva'''
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===NMR Solution Structure of the Viral Receptor Domain of Tva===
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==Overview==
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Tva is the cellular receptor for subgroup A avian sarcoma and leukosis virus (ASLV-A). The viral receptor function of Tva is determined by a 40-residue, cysteine-rich motif called the LDL-A module. Here we report the solution structure of the LDL-A module of Tva, determined by nuclear magnetic resonance (NMR) spectroscopy. Although the carboxyl terminus of the Tva LDL-A module has a structure similar to those of other reported LDL-A modules, the amino terminus adopts a different conformation. The LDL-A module of Tva does not contain the signature antiparallel beta-sheet observed in other LDL-A modules, and it is more flexible than other reported LDL-A modules. The LDL-A structure of Tva provides mechanistic insights into how a simple viral receptor functions in retrovirus entry. The side chains of H38 and W48 of Tva, which have been identified as viral contact residues by mutational analysis, are solvent exposed, suggesting that they are directly involved in EnvA binding. However, the side chain of L34, another potential viral contact residue identified previously, is buried inside of the module and forms the hydrophobic core with other residues. Thus L34 likely stabilizes the Tva structure but is not a viral interaction determinant. In addition, we propose that the flexible amino-terminal region of Tva plays an important role in determining specificity in the Tva-EnvA interaction.
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(as it appears on PubMed at http://www.pubmed.gov), where 11861852 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11861852}}
==About this Structure==
==About this Structure==
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1JRF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Coturnix_japonica Coturnix japonica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JRF OCA].
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1JRF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Coturnix_japonica Coturnix japonica]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JRF OCA].
==Reference==
==Reference==
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[[Category: Calcium cage]]
[[Category: Calcium cage]]
[[Category: Disulfide bond]]
[[Category: Disulfide bond]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:44:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:41:24 2008''

Revision as of 17:41, 1 July 2008

Image:1jrf.png

Template:STRUCTURE 1jrf

NMR Solution Structure of the Viral Receptor Domain of Tva

Template:ABSTRACT PUBMED 11861852

About this Structure

1JRF is a Single protein structure of sequence from Coturnix japonica. Full experimental information is available from OCA.

Reference

Solution structure of the viral receptor domain of Tva and its implications in viral entry., Wang QY, Huang W, Dolmer K, Gettins PG, Rong L, J Virol. 2002 Mar;76(6):2848-56. PMID:11861852

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