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1jsu

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[[Image:1jsu.gif|left|200px]]
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{{STRUCTURE_1jsu| PDB=1jsu | SCENE= }}
{{STRUCTURE_1jsu| PDB=1jsu | SCENE= }}
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'''P27(KIP1)/CYCLIN A/CDK2 COMPLEX'''
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===P27(KIP1)/CYCLIN A/CDK2 COMPLEX===
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==Overview==
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The crystal structure of the human p27Kip1 kinase inhibitory domain bound to the phosphorylated cyclin A-cyclin-dependent kinase 2 (Cdk2) complex has been determined at 2.3 angstrom. p27Kip1 binds the complex as an extended structure interacting with both cyclin A and Cdk2. On cyclin A, it binds in a groove formed by conserved cyclin box residues. On Cdk2, it binds and rearranges the amino-terminal lobe and also inserts into the catalytic cleft, mimicking ATP.
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(as it appears on PubMed at http://www.pubmed.gov), where 8684460 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8684460}}
==About this Structure==
==About this Structure==
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[[Category: Inhibitor]]
[[Category: Inhibitor]]
[[Category: Kinase]]
[[Category: Kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:51:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:44:54 2008''

Revision as of 17:44, 1 July 2008

Image:1jsu.png

Template:STRUCTURE 1jsu

P27(KIP1)/CYCLIN A/CDK2 COMPLEX

Template:ABSTRACT PUBMED 8684460

About this Structure

1JSU is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex., Russo AA, Jeffrey PD, Patten AK, Massague J, Pavletich NP, Nature. 1996 Jul 25;382(6589):325-31. PMID:8684460

Page seeded by OCA on Tue Jul 1 20:44:54 2008

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