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1jss

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[[Image:1jss.gif|left|200px]]
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{{STRUCTURE_1jss| PDB=1jss | SCENE= }}
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'''Crystal structure of the Mus musculus cholesterol-regulated START protein 4 (StarD4).'''
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===Crystal structure of the Mus musculus cholesterol-regulated START protein 4 (StarD4).===
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==Overview==
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The x-ray structure of the mouse cholesterol-regulated START protein 4 (StarD4) has been determined at 2.2-A resolution, revealing a compact alpha/beta structure related to the START domain present in the cytoplasmic C-terminal portion of human MLN64. The volume of the putative lipid-binding tunnel was estimated at 847 A(3), which is consistent with the binding of one cholesterol-size lipid molecule. Comparison of the tunnel-lining residues in StarD4 and MLN64-START permitted identification of possible lipid specificity determinants in both molecular tunnels. Homology modeling of related proteins, and comparison of the StarD4 and MLN64-START structures, showed that StarD4 is a member of a large START domain superfamily characterized by the helix-grip fold. Additional mechanistic and evolutionary studies should be facilitated by the availability of a second START domain structure from a distant relative of MLN64.
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(as it appears on PubMed at http://www.pubmed.gov), where 12011453 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12011453}}
==About this Structure==
==About this Structure==
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[[Category: Start domain]]
[[Category: Start domain]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:51:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:44:54 2008''

Revision as of 17:44, 1 July 2008

Image:1jss.png

Template:STRUCTURE 1jss

Crystal structure of the Mus musculus cholesterol-regulated START protein 4 (StarD4).

Template:ABSTRACT PUBMED 12011453

About this Structure

1JSS is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the Mus musculus cholesterol-regulated START protein 4 (StarD4) containing a StAR-related lipid transfer domain., Romanowski MJ, Soccio RE, Breslow JL, Burley SK, Proc Natl Acad Sci U S A. 2002 May 14;99(10):6949-54. PMID:12011453

Page seeded by OCA on Tue Jul 1 20:44:54 2008

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