1jt6

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{{STRUCTURE_1jt6| PDB=1jt6 | SCENE= }}
{{STRUCTURE_1jt6| PDB=1jt6 | SCENE= }}
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'''Crystal structure of the multidrug binding protein QacR bound to dequalinium'''
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===Crystal structure of the multidrug binding protein QacR bound to dequalinium===
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==Overview==
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The Staphylococcus aureus multidrug binding protein QacR represses transcription of the qacA multidrug transporter gene and is induced by structurally diverse cationic lipophilic drugs. Here, we report the crystal structures of six QacR-drug complexes. Compared to the DNA bound structure, drug binding elicits a coil-to-helix transition that causes induction and creates an expansive multidrug-binding pocket, containing four glutamates and multiple aromatic and polar residues. These structures indicate the presence of separate but linked drug-binding sites within a single protein. This multisite drug-binding mechanism is consonant with studies on multidrug resistance transporters.
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(as it appears on PubMed at http://www.pubmed.gov), where 11739955 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11739955}}
==About this Structure==
==About this Structure==
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[[Category: Qacr]]
[[Category: Qacr]]
[[Category: S. aureus]]
[[Category: S. aureus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:53:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:45:57 2008''

Revision as of 17:45, 1 July 2008

Image:1jt6.png

Template:STRUCTURE 1jt6

Crystal structure of the multidrug binding protein QacR bound to dequalinium

Template:ABSTRACT PUBMED 11739955

About this Structure

1JT6 is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

Structural mechanisms of QacR induction and multidrug recognition., Schumacher MA, Miller MC, Grkovic S, Brown MH, Skurray RA, Brennan RG, Science. 2001 Dec 7;294(5549):2158-63. PMID:11739955

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