1juh

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[[Image:1juh.jpg|left|200px]]
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{{STRUCTURE_1juh| PDB=1juh | SCENE= }}
{{STRUCTURE_1juh| PDB=1juh | SCENE= }}
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'''Crystal Structure of Quercetin 2,3-dioxygenase'''
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===Crystal Structure of Quercetin 2,3-dioxygenase===
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==Overview==
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Quercetin 2,3-dioxygenase is a copper-containing enzyme that catalyzes the insertion of molecular oxygen into polyphenolic flavonols. Dioxygenation catalyzed by iron-containing enzymes has been studied extensively, but dioxygenases employing other metal cofactors are poorly understood. We determined the crystal structure of quercetin 2,3-dioxygenase at 1.6 A resolution. The enzyme forms homodimers, which are stabilized by an N-linked heptasaccharide at the dimer interface. The mononuclear type 2 copper center displays two distinct geometries: a distorted tetrahedral coordination, formed by His66, His68, His112, and a water molecule, and a distorted trigonal bipyramidal environment, which additionally comprises Glu73. Manual docking of the substrate quercetin into the active site showed that the different geometries of the copper site might be of catalytic importance.
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The line below this paragraph, {{ABSTRACT_PUBMED_11839311}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11839311 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11839311}}
==About this Structure==
==About this Structure==
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[[Category: Dioxygenase]]
[[Category: Dioxygenase]]
[[Category: Glycoprotein]]
[[Category: Glycoprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:56:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:54:12 2008''

Revision as of 17:54, 1 July 2008

Image:1juh.png

Template:STRUCTURE 1juh

Crystal Structure of Quercetin 2,3-dioxygenase

Template:ABSTRACT PUBMED 11839311

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure of the copper-containing quercetin 2,3-dioxygenase from Aspergillus japonicus., Fusetti F, Schroter KH, Steiner RA, van Noort PI, Pijning T, Rozeboom HJ, Kalk KH, Egmond MR, Dijkstra BW, Structure. 2002 Feb;10(2):259-68. PMID:11839311

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