1jur

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{{STRUCTURE_1jur| PDB=1jur | SCENE= }}
{{STRUCTURE_1jur| PDB=1jur | SCENE= }}
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'''Solution Structure of Helix III in Xenopus Oocyte 5S rRNA.'''
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===Solution Structure of Helix III in Xenopus Oocyte 5S rRNA.===
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==Overview==
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The solution structure of an oligonucleotide containing the helix III sequence from Xenopus oocyte 5 S rRNA has been determined by NMR spectroscopy. Helix III includes two unpaired adenosine residues, flanked on either side by G:C base-pairs, that are required for binding of ribosomal protein L5. The consensus conformation of helix III in the context provided by this oligonucleotide has the two adenosine residues located in the minor groove and stacked upon the 3' flanking guanosine residue, consistent with biochemical studies of free 5 S rRNA in solution. A distinct break in stacking that occurs between the first adenosine residue of the bulge and the flanking 5' guanosine residue exposes the base of the adenosine residue in the minor groove and the base of the guanosine residue in the major groove. The major groove of the helix is widened at the site of the unpaired nucleotides and the helix is substantially bent; nonetheless, the G:C base-pairs flanking the bulge are intact. The data indicate that there may be conformational heterogeneity centered in the bulge region. The corresponding adenosine residues in the Haloarcula marismortui 50 S ribosomal subunit form a dinucleotide platform, which is quite different from the motif seen in solution. Thus, the conformation of helix III probably changes when 5 S rRNA is incorporated into the ribosome.
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The line below this paragraph, {{ABSTRACT_PUBMED_11575935}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11575935 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11575935}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUR OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUR OCA].
==Reference==
==Reference==
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[[Category: Bulge]]
[[Category: Bulge]]
[[Category: Rna]]
[[Category: Rna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:57:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:55:44 2008''

Revision as of 17:55, 1 July 2008

Image:1jur.png

Template:STRUCTURE 1jur

Solution Structure of Helix III in Xenopus Oocyte 5S rRNA.

Template:ABSTRACT PUBMED 11575935

About this Structure

Full experimental information is available from OCA.

Reference

The structure of helix III in Xenopus oocyte 5 S rRNA: an RNA stem containing a two-nucleotide bulge., Huber PW, Rife JP, Moore PB, J Mol Biol. 2001 Sep 28;312(4):823-32. PMID:11575935

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